As a medical school professor, I was taught to treat obesity and cancer as separate problems.

That was wrong.

A major new JAMA review confirms obesity drives 12 cancer types — and accounts for 10% of ALL new cancer cases in the US. For endometrial and liver cancers, it's up to 50%.

The 5 pathways:
- Adipose tissue inflammation (IL-6, TNF-α)
- DNA damage from oxidative stress
- Altered energy met... https://jamanetwork.com/journals/jama/article-abstract/2832458

#ObesityAndCancer #MetabolicHealth #JAMA #CancerPrevention #WeightLoss

Enes Erul MD (@ErulEnes)

JAMA 편집자 노트는 AI가 학술 작업에 일상적으로 사용되고 있음을 지적합니다. JAMA Network에 제출된 원고에서 AI 사용 공개 비율이 약 2년간 1.7%에서 6.0%로 증가했으며, AI 사용의 약 68%는 주로 언어 다듬기(문장/문법 개선)에 해당합니다. 편집자는 채택 속도에 맞춘 투명성·공개 기준 정비의 필요성을 강조합니다.

https://x.com/ErulEnes/status/2027803449048347018

#jama #academicpublishing #aiusage #aitransparency

Enes Erul MD (@ErulEnes) on X

JAMA Editor’s Note felt like a mirror: AI is now routine in academic work. In JAMA Network submissions, AI-use disclosure rose 1.7%→6.0% in ~2 years; most use is language refinement (~68%). Transparency must keep pace with adoption. 🤖📄🧪 #AI @GlopesMd @DeryaTR_ @jnkath

X (formerly Twitter)

the brewhaha man came to town
staph on my knee is starting to resolve - starting to recover faster - every 3 mos i get nailed

#moderate drinking as a coping mechanism #jama

I guess there was a study that claimed Metformin wasn’t helpful with covid in people who are not obese. This looks like a good rebuttal with some valid points about why the study wasn’t so good.

“Metformin Therapy for Patients With COVID-19 Without Obesity”
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2842942

#metformin #JAMA #covid #LongCovid

This is crazy making. This JAMA article is about how this flu strain is particularly nasty, partly because they didn’t know this would be the predominant one until after vaccines were made & it mentions “respiratory hygiene, such as staying home when you’re sick”, but there’s no mention of prevention.

https://jamanetwork.com/journals/jama/fullarticle/2843197

This person, this pharmacist (?) in the comments, is the only one in this article to talk about how airborne viruses aren’t inevitable & it would be better to not act like they are.

Then the next comment is some clown talking about how it’s best to let our immune system battle it (rather than vaccines or antivirals I guess).

Anyway, the pharmacist’s comment had some links if you’re interested.

Nicola Boyd, PhD Comp. Chemist | Durham University
“The authors state the concerning but not unexpected behaviour of seasonal influenza viruses – that they evolve and mutate rapidly, causing unacceptable levels of illness every year, prompting a never ending arms race for vaccine developers. It is encouraging that the authors do acknowledge that the influenza vaccines are sub-optimal – ‘I wish we had better flu vaccines that, if you got it, you’re not going to get the flu….That’s not the case’. Beyond this however, in common with much of the medical and public health community, the overall outlook remains confined by a narrow and somewhat blinkered mindset.

The underlying fundamental judgement implied here is that respiratory infections are inevitable, and the only reasonable option is downstream mitigations via relatively poorly performing pharmaceutical interventions.

Outside the medical realm, aerosol engineers have a great deal of understanding about how airborne viral transmission occurs and how this can be curtailed. UVC/Far-UVC air and surface disinfection, HEPA/MERV filtration, and ventilation are technologies that can remove and destroy multiple pathogens simultaneously 'outside the human host'. The importance of this latter point cannot be overstated, as it means that pathogens have no mutational space to explore, thus creating an evolutionary dead end for replicating entities. These truly preventative solutions not only reduce the disease burden, but in doing so will also allow us to extract better value from vaccines and anti-virals by significantly slowing the evolutionary process of such troublesome diseases.

I believe that we will only make significant progress if the medical establishment breaks away from the ‘surrender narrative’ that airborne viral infections are inevitable, and starts to integrate medical interventions with engineering solutions for transmission control and potential elimination, in a truly preventative strategy.”

References:
https://www.science.org/doi/10.1126/science.abd9149

https://www.nature.com/articles/s41467-024-47777-5

https://www.nature.com/articles/s41598-024-57441-z

https://pmc.ncbi.nlm.nih.gov/articles/PMC10933500/

#H3N2 #influenza #JAMA #vaccines

A New H3N2 Influenza Strain Is Raising Concerns About This Flu Season

https://jamanetwork.com/journals/jama/fullarticle/2843197/

#Medical #News
from #JAMA
December 19, 2025

#Flu season comes around every year, but a new strain is leading many #GlobalHealth experts to worry that this round may be particularly severe. The strain—a version of the #influenza A(#H3N2) #virus—first appeared in surveillance reports in June, 4 months after the 2025-2026 #InfluenzaVaccine formulation had already been determined, and has been associated with earlier waves of influenza outbreaks in #Canada, #Japan, and the #UK.

#health

#DNA #Jama Οι κορυφαίες ιατρικές έρευνες του 2025, σύμφωνα με το περιοδικό JAMA https://www.zougla.gr/ygeia/erevnes/oi-koryfaies-iatrikes-erevnes-tou-2025-symfona-me-to-periodiko-jama/?utm_source=dlvr.it&utm_medium=mastodon
Trump admin axed 383 active clinical trials, dumping over 74K participants https://arstechni.ca/5B3Q #clinicaltrials #Health #grants #JAMA #NIH
Trump admin axed 383 active clinical trials, dumping over 74K participants

It’s a “violation of foundational ethical principles of human participant research.”…

Ars Technica