The incidence of invasive fungal infections has increased, resulting in considerable morbidity and mortality, especially in immunocompromised individuals.
Shinohara et al. evaluated various alkyl polyamine compounds (APCs) that could deprive fungi of essential transition metals. A cyclic APC with three pyridylmethyl groups, APC6, was found to have high antifungal activity against a wide range of Candida species, including MDR C. auris:
https://doi.org/10.1093/jacamr/dlad155
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This study finds the term ‘silent pandemic’ phrase may reduce threat perception and mobilisation intentions. Best to avoid it in health communication about antibiotic resistance:
https://doi.org/10.1093/jacamr/dlae018
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Schellong et al. provide a brief report on OPAT with cefiderocol for post-traumatic osteomyelitis:
https://doi.org/10.1093/jacamr/dlae015
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Powell et al. examined healthcare workers’ views on a penicillin allergy de-labelling patient pathway:
https://doi.org/10.1093/jacamr/dlae014
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Khan et al. determined the consumption of antimicrobials and new #COVID19 treatments before and during the pandemic at the Mid Yorkshire Teaching NHS Trust, advocating for #AMS and future preparedness:
https://doi.org/10.1093/jacamr/dlae013
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Pharmacy technicians can be upskilled in the management of acne and associated #AntimicrobialStewardship by using the TARGET toolkit:
https://doi.org/10.1093/jacamr/dlae011
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In this article, Baltas et al. show that ciprofloxacin prophylaxis during haematopoetic cell transplantation led to fewer infection episodes and reduced exposure to wide spectrum treatment antimicrobials but an increased burden of antimicrobial resistance in breakthrough infections:
https://doi.org/10.1093/jacamr/dlae010
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Moving towards #OneHealth surveillance of #AMR in France: Collineau et al. evaluated the level and quality of collaboration across the human, animal and environmental sectors:
https://doi.org/10.1093/jacamr/dlae008
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This in vitro study by Huang et al. demonstrated low cefiderocol MICs for multidrug-resistant A. baumannii, P. aeruginosa, B. cepacia complex and S. maltophilia:
https://doi.org/10.1093/jacamr/dlae006
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Tackling #AMR by supporting global accreditation of AMS programmes. Reflections on the first year of the Global Antimicrobial Stewardship Accreditation Scheme (GAMSAS) and plans for future spread:
https://doi.org/10.1093/jacamr/dlae007
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