NewsletterTFMar 4

Indian Institute of Science Researchers Identify Brain Mechanism for Stress-Induced Itch Suppression

IISc researchers found a brain pathway that stops itching when stressed. This could help treat long-term itch problems. Learn how it works.

#IIScResearch, #BrainScience, #ItchRelief, #StressResponse, #MedicalDiscovery

https://newsletter.tf/iisc-brain-study-stress-stops-itch/

IISc Brain Study Explains Why Stress Stops Itching for Some People

IISc researchers found a brain pathway that stops itching when stressed. This could help treat long-term itch problems. Learn how it works.

NewsletterTFMar 4

Scientists at IISc discovered a brain circuit that turns off itching during stress. This finding is important because it could lead to new ways to help people with constant itching.

#IIScResearch, #BrainScience, #ItchRelief, #StressResponse, #MedicalDiscovery

https://newsletter.tf/iisc-brain-study-stress-stops-itch/

IISc Brain Study Explains Why Stress Stops Itching for Some People

IISc researchers found a brain pathway that stops itching when stressed. This could help treat long-term itch problems. Learn how it works.

Angstrom MineralsJul 12, 2024

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#Zinc #SkinHealth #AntiInflammatory #ItchRelief #Health #Wellness #AngstromMinerals #FeelComfortable

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Health365Info.comDec 3, 2023
New ITCH Discovery: Human & Pets #itchrelief #dogitch #itchycat #itch
PLOS BiologyJun 23, 2023
Modulating itch sensation: #CryoEM structure of human #ItchReceptor MRGPRX1-Gq complex with agonist reveals a unique agonist recognition pattern compared to other MRGPRXs, with potential therapeutic implications for #ItchRelief & #analgesia #PLOSBiology https://plos.io/3NLqpAA
Mechanism of agonist-induced activation of the human itch receptor MRGPRX1

Mas-related G-protein-coupled receptors X1-X4 (MRGPRX1-X4) are 4 primate-specific receptors that are recently reported to be responsible for many biological processes, including itch sensation, pain transmission, and inflammatory reactions. MRGPRX1 is the first identified human MRGPR, and its expression is restricted to primary sensory neurons. Due to its dual roles in itch and pain signaling pathways, MRGPRX1 has been regarded as a promising target for itch remission and pain inhibition. Here, we reported a cryo-electron microscopy (cryo-EM) structure of Gq-coupled MRGPRX1 in complex with a synthetic agonist compound 16 in an active conformation at an overall resolution of 3.0 Å via a NanoBiT tethering strategy. Compound 16 is a new pain-relieving compound with high potency and selectivity to MRGPRX1 over other MRGPRXs and opioid receptor. MRGPRX1 was revealed to share common structural features of the Gq-mediated receptor activation mechanism of MRGPRX family members, but the variable residues in orthosteric pocket of MRGPRX1 exhibit the unique agonist recognition pattern, potentially facilitating to design MRGPRX1-specific modulators. Together with receptor activation and itch behavior evaluation assays, our study provides a structural snapshot to modify therapeutic molecules for itch relieving and analgesia targeting MRGPRX1.