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Psychedelic drug DOI activates specific brain neurons to ease anxiety

The psychedelic DOI reduces anxiety by activating specific interneurons in the ventral hippocampus without causing hallucinations, according to new research, suggesting potential for targeted anxiety treatments .

Functional networks of inhibitory neurons orchestrate synchrony in the hippocampus

Interneurons control the timing of activation of excitatory neurons, but how single interneurons affect synchrony in vivo is unclear. This study shows that CA1 hippocampus interneurons form a functionally connected network that promotes synchrony between pyramidal cells at the single neuron level.

Fast-spiking interneuron detonation drives high-fidelity inhibition in the olfactory bulb

Inhibitory circuits in the mammalian olfactory bulb shape information as it propagates from peripheral receptors to the downstream cortex. This study reveals that fast-spiking interneurons perisomatically inhibit projection neurons in the mammalian olfactory bulb via synaptic detonation.

Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells

Id2 GABAergic interneurons represent a fourth major group of local inhibitory neurons that includes neurogliaform cells, and these neurons can be targeted using intersectional genetics, revealing their distinctive connectivity and in vivo activity properties.