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Google Docs
Diagnosing inflammatory diseases with synthetic peptides

Common inflammatory disorders such as ulcerative colitis and Crohn's disease can be diagnosed or monitored by measuring the protein calprotectin in stool samples, while serum levels of calprotectin could be used to monitor the inflammation status in rheumatoid arthritis. Calprotectin concentrations in patient samples are typically determined using antibodies that bind and detect the protein, for example, in lateral flow assays like the now all-too-familiar home COVID-19 test kits.

Phys.org

🦠 Although #CellDeath is essential for defense against viral infections, it can also lead to severe disease. Manolis Pasparakis @UniCologne explains more
👉 https://bit.ly/42jdlHS

@HorizonMagEU @CECAD_ @UniCologne_D7
#inflammatorydiseases #immunology https://www.youtube.com/shorts/q2UtCbyhWUg

🐦🔗: https://n.respublicae.eu/ERC_Research/status/1658004326172991488

Cell death, a life-giving event, can also trigger severe disease

Cell death, which might sound unwelcome, is actually essential for keeping every person alive. The process, tightly regulated by the body, destroys old or damaged cells to make way for new ones. At the same time, cells invaded by microbes are eliminated to fight infections.

Horizon Magazine
Scientists unearth potential new therapeutic target for inflammatory diseases such as lupus and sepsis

Scientists working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and—in doing so—unearthed a potential new therapeutic target.

Medical Xpress
Digital twin opens way to effective treatment of inflammatory diseases

Inflammatory diseases like rheumatoid arthritis have complex disease mechanisms that can differ from patient to patient with the same diagnosis. This means that currently available drugs have little effect on many patients. Using so-called digital twins, researchers at Karolinska Institutet have now obtained a deeper understanding of the "off and on" proteins that control these diseases. The study, which is published in Cell Reports Medicine, can lead to more personalized drug therapies.