MrMed : Online PharmacyMar 5

How serious is organ transplant rejection? Learn about the three types of rejection (hyperacute, acute, and chronic), common risks, and the 2026 recovery timeline for transplant recipients.
https://bresdel.com/blogs/1439099/How-Serious-Is-Organ-Transplant-Rejection-Risks-and-Recovery-Timeline

#OrganTransplant #TransplantRecovery #HealthTips #OrganDonation #Immunosuppression #MedicalNews2026 #KidneyTransplant #LiverTransplant

Howard Smith MD, AMDec 8
Transplantation Without Immunosuppression. Stanford transplant immunologists have developed a transplantation technique employing an induced hybrid or chimeric immune system in the recipient. #transplantation #diabetes #hybrid #stemcell #immunosuppression
https://www.instagram.com/p/DSBPxskDW56/
Howard G. Smith MD, AM on Instagram: "Transplantation Without Immunosuppression Organ transplantation is a miracle for those with failing kidneys, hearts, or livers. With those transplants comes the need for lifelong immunosuppression and the risk of infection as well as graft failure due to an immune attack. With the hope of eliminating the need for this immunosuppression, Stanford transplant immunologists and developmental biologists have developed a transplantation technique employing an induced hybrid or chimeric immune system in the recipient. They now publish their studies using this system to successfully transplant insulin-producing pancreatic islet cells in diabetic mice. The researchers performed the dual transplantation of the pancreatic islet cells but also white cell-forming stem cells from the genetically-mismatched donor. To permit the stem cells to escape rejection and develop the hybrid immune system, the recipient animals received a one-time pretreatment with low dose radiation and several immunosuppressive agents. All of the animals so treated developed the hybrid-chimeric immune system that allowed them to remain tolerant and fully accept the islet cell transplants without further immunosuppression and with excellent islet cell insulin production. The recipients’ new chimeric immune system did not attack their own cells or organs, so-called graft versus host disease. This is such a ground-breaking development, let’s review it with a diagram from the published paper. Pancreatic islet cells and bone marrow cells from the un-related donor are harvested and transplanted into the diabetic recipient whose immune system has been temporarily weakened with low dose radiation and anti-T cell antibodies. The recipient’s immune system becomes permanently tolerant to the donor’s cells and the transplanted islet cells remain functional and produce insulin curing the diabetes. This hybrid immune system does not attack the recipients cells either. This opens the door for not only islet cell transplantation in humans but also immunosuppression-free heart, liver, and kidney transplantation. #transplantation #diabetes #hybrid #stemcell #immunosuppression"

Researchers at Stanford have developed a technique to induce a hybrid immune system in transplant recipients, making it possible to transplant organs without the need for lifelong immunosuppression. This innovation could lead to a new era of immunotherapy and improve the lives of millions.

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Howard Smith MD, AMSep 18, 2025
How Long Is Your RSV Immunization Protective? The answer comes from a Vanderbilt University helmed study of subjects in 20 states. #rsv #vaccination #hospitalization #immunosuppression #cardiovascular
https://www.instagram.com/p/DOweKVlCSKY/
Howard G. Smith MD, AM on Instagram: "How Long Is Your RSV Immunization Protective? A single RSV vaccination is protective for vulnerable adults through 2 consecutive RSV seasons. This the conclusion of a multicenter, collaborative study headed by investigators at Vanderbilt University. They studied 6958 persons 60 years or older hospitalized with respiratory illness in 20 states from 2023 into 2025. The vaccine effectiveness for preventing a hospitalization with Respiratory Syncytial Virus was 69% during the first year following vaccination and 48% during the second year yielding an average effectiveness over the 2 years of 58%. The year-to-year change was not significant. Drilling down on the study population, the 2 season vaccine effectiveness was lower for immunocompromised patients at 30% compared with 67% for the immunocompetent and lower at 58% or those with cardiovascular disease versus 80% for those without it. Work is now ongoing to determine when individuals with complicating medical conditions such as immunosuppression and/or cardiovascular disease should receive RSV boosters. Also expect to see recommendations from infectious disease specialists regarding when otherwise healthy older individual should receive boosters. https://jamanetwork.com/journals/jama/fullarticle/2838490 #rsv #vaccination #hospitalization #immunosuppression #cardiovascular"

0 likes, 0 comments - drhowardsmithreports on September 18, 2025: "How Long Is Your RSV Immunization Protective? A single RSV vaccination is protective for vulnerable adults through 2 consecutive RSV seasons. This the conclusion of a multicenter, collaborative study headed by investigators at Vanderbilt University. They studied 6958 persons 60 years or older hospitalized with respiratory illness in 20 states from 2023 into 2025. The vaccine effectiveness for preventing a hospitalization with Respiratory Syncytial Virus was 69% during the first year following vaccination and 48% during the second year yielding an average effectiveness over the 2 years of 58%. The year-to-year change was not significant. Drilling down on the study population, the 2 season vaccine effectiveness was lower for immunocompromised patients at 30% compared with 67% for the immunocompetent and lower at 58% or those with cardiovascular disease versus 80% for those without it. Work is now ongoing to determine when individuals with complicating medical conditions such as immunosuppression and/or cardiovascular disease should receive RSV boosters. Also expect to see recommendations from infectious disease specialists regarding when otherwise healthy older individual should receive boosters. https://jamanetwork.com/journals/jama/fullarticle/2838490 #rsv #vaccination #hospitalization #immunosuppression #cardiovascular".

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Howard Smith MD, AMAug 26, 2025
Novel Approach To Transplant Immunosuppression directs the body’s immune system to censor itself permitting transplanted human organs to flourish without medicinal immunosuppression. #transplantation #immunosuppression #Treg #antibodies #presensitized
https://www.instagram.com/p/DN06krQ2q-f/
Howard G. Smith MD, AM on Instagram: "Novel Approach To Transplant Immunosuppression Immunologists at the Medical University of South Carolina have found a way to direct the body’s immune system to censor itself permitting transplanted human organs to flourish with medicinal immunosuppression. Their study appeared recently in Frontiers in Immunology. The investigators genetically engineered so-called regulatory T cells, Treg lymphocytes, to selectively destroy those B lymphocytes programmed to produce the antibodies that attack transplanted organs. This self-immunosuppression could extend the life of transplanted organs and permit so-called presensitized patients with pre-existing B lymphocytes ready to churn out anti-organ antibodies an opportunity for successful transplantation. Let’s hope clinical trials demonstrate the utility of this approach. https://www.news-medical.net/news/20250817/Genetically-engineered-immune-cells-show-promise-for-preventing-organ-rejection.aspx https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1601385/full #transplantation #immunosuppression #Treg #antibodies #presensitized"

0 likes, 0 comments - drhowardsmithreports on August 26, 2025: "Novel Approach To Transplant Immunosuppression Immunologists at the Medical University of South Carolina have found a way to direct the body’s immune system to censor itself permitting transplanted human organs to flourish with medicinal immunosuppression. Their study appeared recently in Frontiers in Immunology. The investigators genetically engineered so-called regulatory T cells, Treg lymphocytes, to selectively destroy those B lymphocytes programmed to produce the antibodies that attack transplanted organs. This self-immunosuppression could extend the life of transplanted organs and permit so-called presensitized patients with pre-existing B lymphocytes ready to churn out anti-organ antibodies an opportunity for successful transplantation. Let’s hope clinical trials demonstrate the utility of this approach. https://www.news-medical.net/news/20250817/Genetically-engineered-immune-cells-show-promise-for-preventing-organ-rejection.aspx https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1601385/full #transplantation #immunosuppression #Treg #antibodies #presensitized".

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Howard Smith MD, AMAug 17, 2025
Gene Editing Allows Pancreatic Islet Cell Transplantation Without Immunosuppression. #diabetes #insulin #isletcells #transplantation #geneediting #immunosuppression
https://www.instagram.com/p/DNd6KltPeD_/
Howard G. Smith MD, AM on Instagram: "Gene Editing Allows Pancreatic Islet Cell Transplantation Without Immunosuppression Transplantation immuno-geneticists at Sweden’s Uppsala University Hospital have successfully used gene editing to modify human pancreatic islet cells such that these transplants are more histocompatible, survive longer, and function better. Their single patient case report appeared in a recent issues of the New England Journal of Medicine. The recipient is a 42-year-old male juvenile-onset insulin-dependent diabetic. The researchers utilized CRISPR-Cas12b gene editing technology to delete genes that code for incompatible cell surface antigens while adding genes coding for protective antigens thereby making the donor pancreatic cells invisible to the recipient’s immune system. Over a 12-week period, the limited number of gene-edited islet cells available for transplantation were able to reduce but not totally eliminate the recipients insulin requirement. This proved the viability and functional integrity of the transplanted islet cells suggesting that transplantation of a larger complement of islet cells could provide a recipient’s total insulin requirement therapy curing diabetes without the need for ongoing immunosuppression with its often toxic side effects. https://medicalxpress.com/news/2025-08-gene-islet-transplant-human-functional.html https://www.nejm.org/doi/10.1056/NEJMoa2503822 #diabetes #insulin #isletcells #transplantation #geneediting #immunosuppression"

0 likes, 0 comments - drhowardsmithreports on August 17, 2025: "Gene Editing Allows Pancreatic Islet Cell Transplantation Without Immunosuppression Transplantation immuno-geneticists at Sweden’s Uppsala University Hospital have successfully used gene editing to modify human pancreatic islet cells such that these transplants are more histocompatible, survive longer, and function better. Their single patient case report appeared in a recent issues of the New England Journal of Medicine. The recipient is a 42-year-old male juvenile-onset insulin-dependent diabetic. The researchers utilized CRISPR-Cas12b gene editing technology to delete genes that code for incompatible cell surface antigens while adding genes coding for protective antigens thereby making the donor pancreatic cells invisible to the recipient’s immune system. Over a 12-week period, the limited number of gene-edited islet cells available for transplantation were able to reduce but not totally eliminate the recipients insulin requirement. This proved the viability and functional integrity of the transplanted islet cells suggesting that transplantation of a larger complement of islet cells could provide a recipient’s total insulin requirement therapy curing diabetes without the need for ongoing immunosuppression with its often toxic side effects. https://medicalxpress.com/news/2025-08-gene-islet-transplant-human-functional.html https://www.nejm.org/doi/10.1056/NEJMoa2503822 #diabetes #insulin #isletcells #transplantation #geneediting #immunosuppression".

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MrMed : Online PharmacyJul 28, 2025

Understand why organ rejection occurs after transplant, recognize key symptoms, and discover vital strategies to prevent it for a healthier recovery.
https://mrmedonlinepharmacy.blogspot.com/2025/05/top-reasons-for-organ-rejection-after.html

#OrganRejection #TransplantHealth #Immunosuppression #PostTransplantCare #OrganDonor

Top Reasons for Organ Rejection After Transplant & How to Overcome It

Imagine getting a second shot at life only to find your body fighting it. Sounds like a cruel twist, right? But that’s what organ rejection ...

preLightsMay 21, 2025

Macrophages sense and adapt. Immuno-mechanics meets cancer research.

Roberto Amadio highlights recent work from Wenyan Xie and colleagues.

Roberto: “The huge amount of data (…) is of high value not only to cancer biologists, but also to cell biologists and clinicians”.

#preLight ⬇️ 👀

👉 https://prelights.biologists.com/highlights/an-immunomechanical-checkpoint-pyk2-governs-monocyte-to-macrophage-differentiation-in-pancreatic-cancer/

#biology #biomechanics #immunosuppression #macrophages #cancer #pyk2

An immunomechanical checkpoint PYK2 governs monocyte-to-macrophage differentiation in pancreatic cancer - preLights

Macrophages sense and adapt. Immuno-mechanics meets cancer research

preLights
Hacker NewsApr 25, 2025

Tumor-derived erythropoietin acts as immunosuppressive switch in cancer immunity

https://www.science.org/doi/10.1126/science.adr3026

#HackerNews #TumorDerivedErythropoietin #Immunosuppression #CancerImmunity #ScienceResearch #HealthInnovation

Benjamin Carr, Ph.D. 👨🏻‍💻🧬Jan 8, 2025
#Sana’s cell therapy may be ‘transformative cure’ for type 1 #diabetes
#Biotech is evaluating UP421, donor-derived allogeneic primary islet cell therapy, as #T1D treatment that doesn’t require #immunosuppression. Four weeks after cells were transplanted into patient’s arm, therapy had avoided immune rejection and was tied to consistent levels of c-peptide expression—a biomarker that indicates if the transplanted beta cells are producing #insulin.
https://www.fiercebiotech.com/biotech/sanas-cell-therapy-may-be-transformative-cure-type-1-diabetes-analysts
https://archive.ph/dT0Vd
Vivienne DunstanSep 11, 2024
So heavily sedated and sleeping at mo (among other increased neuro symptoms) as latest consultant-pushed try at getting my immunosuppression dose a bit lower fails. Glum from it all! Grateful to manage anything productive in the circumstances :) Happy managed historical research late this afternoon. #neuro #autoimmune #immunosuppression #vasculitis #cerebralVasculitis #illness #chronicIllness