halama_immunoStructural #Immunobiology in translation: tertiary lymphoid structures are "immunological mini-organs" and herald active #ImmuneSurveillance especially in solid #cancers , where they are linked to #Immunotherapy responses. #Immunology in the clinic for #sarcoma and other tumors
https://www.nature.com/articles/s41591-022-01821-3
https://www.nature.com/articles/s41591-022-01821-3
Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort - Nature Medicine
In a trial of patients with soft-tissue sarcomas, clinical outcome measures following anti-PD-1 treatment were better in a cohort prospectively selected for the presence of intratumoral tertiary lymphoid structures than in other cohorts where most patients lacked these structures.
Hao Yin