Destille
😋
#nudechef #nakedchef #nakedcooking #nudecooking #nudisme #naturist #FBN #IFN# #getnaked
Khurram Wadee ✅#IFN and the #NGC7771 Group
#Astronomy #Picture of the Day
TheBinderLabFinally, it’s out! I must say, I am really, really fond of this paper– if you are into #innateimmunity, the #antiviralresponse and #interferon, I think you may enjoy reading it:
https://www.life-science-alliance.org/content/6/10/e202302059
Nothing spectacularly new, but very comprehensive characterization of the #RIGI and #IFN pathway!
High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response
RIG-I recognizes viral dsRNA and activates a cell-autonomous antiviral response. Upon stimulation, it triggers a signaling cascade leading to the production of type I and III IFNs. IFNs are secreted and signal to elicit the expression of IFN-stimulated genes, establishing an antiviral state of the cell. The topology of this pathway has been studied intensively, however, its exact dynamics are less understood. Here, we employed electroporation to synchronously activate RIG-I, enabling us to characterize cell-intrinsic innate immune signaling at a high temporal resolution. Employing IFNAR1/IFNLR-deficient cells, we could differentiate primary RIG-I signaling from secondary signaling downstream of the IFN receptors. Based on these data, we developed a comprehensive mathematical model capable of simulating signaling downstream of dsRNA recognition by RIG-I and the feedback and signal amplification by IFN. We further investigated the impact of viral antagonists on signaling dynamics. Our work provides a comprehensive insight into the signaling events that occur early upon virus infection and opens new avenues to study and disentangle the complexity of the host–virus interface.
Gabriele PollaraSome evidence type I IFN being beneficial in airway infections.
But lots of caveats, context-specific issues, mouse models, etc....
#IFN #Interferon #bacteria #infection #MAIT #immunology #Science @JExpMed
https://rupress.org/jem/article/220/10/e20230037/276132/Type-I-interferons-drive-MAIT-cell-functions?guestAccessKey=9a754261-0c2a-4913-b3b7-d98c2395c025&utm_source=NewJournalContent%27&%27utm_campaign%27=%27JEM%27&%27utm_medium%27=%27Email&nbd=28080031447&nbd_source=campaigner&_ccCt=g843-2pnqf6-cox1lz-cwe4ixj5
Achillebro👨🏼⚕️Exciting #JobOpening for entry level Bioinformatician to join our team team at CIML! You will work with my team and use scRNAseq on intestinal epithelial cells to understand how #IFN modulate tissue repair in the intestine and to develop pipelines to analyze the intestinal #microbiota and its effect on homeostasis.
You will work in the framework of the CB2M core, where #bioinformaticians collaborate and train each other to develop new skills Apply now! Send CV and Motivation letter.
You will work in the framework of the CB2M core, where #bioinformaticians collaborate and train each other to develop new skills Apply now! Send CV and Motivation letter.
Michael GassnerThe Central Bank of Sudan (@CentralBank_SD) has published a list of banks and financial institutions that are officially licensed to operate and practice their banking and finance businesses in the country. lnkd.in/gj8vAGeq #REDmoney #IFN #IslamicFinance #CBOS https://twitter.com/IFN_news/status/1640945121972867072?utm_source=dlvr.it&utm_medium=mastodon #liked #link
Islamic Finance News on Twitter
“The Central Bank of Sudan (@CentralBank_SD) has published a list of banks and financial institutions that are officially licensed to operate and practice their banking and finance businesses in the country. https://t.co/DjP2cUZJ56 #REDmoney #IFN #IslamicFinance #CBOS”
CBDCs may have adverse macroeconomic consequences, particularly for Islamic banking systems. The IMF warns of deposit disintermediation and liquidity risk in its latest working paper. lnkd.in/gUaBxSE2 #REDmoney #IFN #IslamicFinance #CBDCs #IslamicBanking #IMF https://twitter.com/IFN_news/status/1638097065711665152?utm_source=dlvr.it&utm_medium=mastodon #tweet #link
Clément Piel 🔭✨🌌A wide field picture taken from my backyard in February: M81 (Bodes’s galaxy), M82 (cigar galaxy) along with many small galaxies in the Ursa Major constellation. On the foreground, clouds of gas and dust (integrated flux nebulae, IFN) are faintly illuminated by the light of our home galaxy, the Milky Way.
Total exposure time: 30h
Processing: Siril, Pixinsight, DxO Photolab
Lucie EtienneThrilled🥳 to have our latest work, led by awesome PhDstudent @Alexandre_Lgrnd
out @biorxiv
preprint!🎆
We looked for anti-#HIV effectors of #IFN #immune response… and we found #SAMD9L & its key active site, also implicated in #genetic #diseases!
A (long) 🧵 here : https://twitter.com/Lucie_Virevolte/status/1616345945225969664?s=20&t=iRO0DCWe7mPViB5Tmilp2g
The preprint here:
https://www.biorxiv.org/content/10.1101/2023.01.19.524725v1
Lucie Etienne on Twitter
“Thrilled🥳 to have our latest work, led by awesome PhDstudent @Alexandre_Lgrnd out @biorxiv preprint!🎆 We looked for anti-#HIV effectors of #IFN #immune response… and we found #SAMD9L & its key active site, also implicated in #genetic #diseases! A 🧵 1/ https://t.co/v1vjzKNyJL”