⚡️ How does the Hv1 proton channel conduct protons faster than diffusion should allow?

🔗 Fluctuating hydrogen-bond network of the Hv1 ion channel. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.021

📚 CSBJ: https://www.csbj.org/

#Biophysics #ProtonChannel #MolecularDynamics #StructuralBiology #HydrogenBonding #IonChannels #ProtonTransport #Hv1

Reduced #Likelihood of #Hospitalization with #JN1 or #HV1 #SARS-CoV-2 #Variants Compared to #EG5 Variant, J Infect Dis.: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae364/7717186?utm_source=advanceaccess&utm_campaign=jid&utm_medium=email&nbd=25018031857&nbd_source=campaigner

JN.1 and HV.1 variants may be associated with a lower #risk of severe illness. The severity of #COVID19 may have attenuated as predominant circulating SARS-CoV-2 lineages shifted from EG.5 to HV.1 to JN.1.

Update for 2/02/2024!

Good Morning SARS2PAians!

I hope you're staying dry with all this winter rain! (Sorry I haven't mirrored on Fedi for a while, i had major important stuff going on.)

There's no new CDC stuff today, but also not much new info to write about in total, JN.1.11 doesn't seem to be taking off right now, and numbers are still doing very well in spite of colder weather (when air cleaning and freshening is a bit more difficult).

THIS IS GOOD! I don't want to have any more news here ever! 🎊

__________
VOCs

Nationally, nothing different yet. JN.1 and JN.1.4 still at the top. JN.1.11 still way down at 0.13% and though it's in 5 states and a few more sequences have been found, it hasn't risen above 1% yet.: https://ibb.co/wgZHftH

__________
Wastewater

Nationally, the decline is starting to level off a bit. Hopefully it continues down after more data is collected.: https://ibb.co/MkcDDX5

Regionally, the West is ticking a bit upwards while everyone else is levelling off.: https://ibb.co/kXdhcTJ

In PA, the 5 stations reporting to Biobot are still doing fabulously. Luzerne and Lackawanna still quite above the national average though.: https://ibb.co/M1KzWJy

According to PA's own wastewater monitoring site numbers are holding steady through the state except thre's an uptick in Franklin Co and over by Pottstown.: https://ibb.co/n3hfVrY

FranklinCo: https://ibb.co/VCb9Z9N

Pottstown: https://ibb.co/0Jg6Gy8

Please use caution to keep these numbers from going back up and causing life, learning, and financial loss.

I just want to shoutout Erie Co since I lost track of there, Erie doesn't report to Biobot but it IS on the PA Wastewater dashboard.

It's not only that Erie's numbers are low, it's that (except for a post-holiday small rise) the absolute baseline there is going down!! Look at that. : https://ibb.co/RyVt4bn

That's amazing. Every county, State, and territories' chart should look like this.

     Thank you Erie!     

Another short update is a good update. Please keep using caution especially with at-risk people and in large public gatherings. Wear a quality respirator in places where there is tightly enclosed space with little ventilation (elevators, restrooms, large public closets, etc.)

Keep that air fresh and clean and we'll be fantastic by Spring! ❄️❄️🌷

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

𝗟𝗔𝗧𝗘𝗦𝗧 𝗨𝗞 #COVID19

🧪𝗖𝗮𝘀𝗲𝘀 — weekly
🔻5,255

🧮𝗧𝗼𝗽 𝗩𝗮𝗿𝗶𝗮𝗻𝘁𝘀
#JN1 #HV1 #EG51

🏥𝗛𝗼𝘀𝗽𝗶𝘁𝗮𝗹 𝗔𝗱𝗺𝗶𝘀𝘀𝗶𝗼𝗻𝘀 — weekly
🔺3,401

🕯️𝗗𝗲𝗮𝘁𝗵𝘀 — weekly
🔺388

🕯️𝗧𝗢𝗧𝗔𝗟 𝗗𝗲𝗮𝘁𝗵𝘀
🔺235,416

➡️http://PMP-Magazine.com/covid-19-today/

#COVIDisNotOver 😷

Update for 1/22/2024!

Good Morning SARS2PAians!

Warmer temperatures are ahead, finally, after this bitter cold spell.❄️❄️❄️

__________
VOCs

There's not much new info out there and of course JN.1 and its child JN.1.4 still dominate the variant leaderboard, so this update will be brief as I have family stuff to do this morning anyway.

It's all going to be about closely watching JN.1.11 (JN-one-eleven).

It's now in 5 states as now it's been found in Washington State, and is spreading blazingly fast in India.

JN.1.11 is now accounting for 0.13% of all random sequencing in the US, up from 0.8%. (Yes, it matters to watch it at those low numbers. Low numbers become top leaderboard numbers eventually!).: https://ibb.co/q92Mccf

__________
CDC

The new hospital admits map looks very much improved since last time. Still some increased activity in Philly, Pike Co, and Lawrence Co. Significant increases in Tioga.: https://ibb.co/n6YqkGj

The Northeast US still struggles with lots of occupied inpatient beds. Lots of increases here as COVID filters through the medical system. Increases from Wayne Co down southwest through Huntingdon Co, over to Jefferson Co and up to Potter and McKean.: https://ibb.co/cyzjP7j

ICU Beds now rising through the State too, especially in Berks, Lancaster, Franklin Co up through to Centre, and the northwest corner of the State excluding Crawford Co.: https://ibb.co/wNWptSH

The 3-month death metric unfortunately remains high in most states including PA, and if you compare to last week, this number is increasing steadily in a lot of States.: https://ibb.co/9TNjnkW

We are sadly experiencing over 300 deaths a month from COVID, 1004 deaths in the past 3 months alone.

❄️❄️❄️Don't become a statistic! Please keep wearing those quality respirators, keep the air clean, be aware of social contacts, and get those vaccinations! 😷❄️❄️❄️

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

𝗟𝗔𝗧𝗘𝗦𝗧 𝗨𝗞 #COVID19

🧪𝗖𝗮𝘀𝗲𝘀 — weekly
🔻6,117

🧮𝗧𝗼𝗽 𝗩𝗮𝗿𝗶𝗮𝗻𝘁𝘀
#JN1 #HV1 #EG51

🏥𝗛𝗼𝘀𝗽𝗶𝘁𝗮𝗹 𝗔𝗱𝗺𝗶𝘀𝘀𝗶𝗼𝗻𝘀 — weekly
🔻3,298

🕯️𝗗𝗲𝗮𝘁𝗵𝘀 — weekly
🔺301

🕯️𝗧𝗢𝗧𝗔𝗟 𝗗𝗲𝗮𝘁𝗵𝘀
🔺235,028

➡️http://PMP-Magazine.com/covid-19-today/

#COVIDisNotOver 😷

Update for 1/19/2024!

Good Morning SARS2PAians!

So. How 'bout that snow? ❄️❄️❄️

Please be cautious and don't travel today if you don't have to! (And don't travel even if you do have to, if you can help it!)

There's no new CDC map stuff today.

__________
VOCs

Nationally, JN.1 at the top of the leaderboard at over 32% of sequencing.: https://ibb.co/vsK3j09

Please remember ALL sequencing is very slow so these numbers are delayed by weeks. Its child JN.1.4 in second place at over 16%.

In PA, JN.1 and its child mutation JN.1.4 at the top of the chart, reflecting naitonal levels.: https://ibb.co/Bcp6Skk

In NY/NJ, numbers also reflect national levels, ans the first few successful lineages are JN.1, JN.1.4, and HV.1.: https://ibb.co/WBk99sG

XDD is a recombinant that has potential to keep up with and even surpass JN.1.

__________
Lineage News

I want to bring your attention to two potentially problematic new mutations: Previously mentioned XDD (a recombo of EG.5.1.1 and JN.1,) and also especially JN.1.11.

Note: That is J-N-ONE-ELEVEN, and I'll hashtag it here on the Fediverse as #JN1Eleven so it won't get confused with other names like JN.1.1.1 or JN.11.1. Understanding the correct lineage name is vital in tracking!

JN.1.11 has a bonkers high estimated fitness (ability to reproduce, infect, take over the lineage leaderboard etc.) based on genomic info alone.: https://ibb.co/J28MbXh

It was only sequenced this month and is already in 5 countries: India, USA, Singapore, Israel, and the UK.

It's already in at least 4 US States: TX, CO, MD and NC.: https://ibb.co/vDhvmX2

Reminder that the JN.x.y series also as a whole has a bonkers high estimated fitness and binding ability based on genomics alone that you can see here on the ACE2/Immune Escape estimation graph.: https://ibb.co/cJ7dLRT

Numbers in wastewater are starting to go down from the original JN.1, but the trouble with this JN.1 clan is it mutates quickly AND all of it is fast. It has the potential to raise the absolute baseline high and keep it there so it never goes down IF we all do not practice some form of source control.

Schools as they open will contribute to rising cases and increased absences all over the place, for kids AND for adults. The way to combat this is source control.

__________
Wastewater

Nationally, SARS2 in wastewater starting to decline.: https://ibb.co/ftKcw5N

Regionally, the Northeast on a sharp downturn and the rest of the regions holding steady or ever so slightly declining.: https://ibb.co/KbjPYLR

Please don't get comfy with this until we know how schoolkids are going to fare.

In PA, the 5/11 Biobot up-to-date sheds are showing a promising downturn, ChesterCo and BucksCo down to meeting the national average level again.: https://ibb.co/0MTv8cm

MontCo is back to smashing it going BELOW national levels!

According to the PA DOH wastewater site (thank you so much to a supercool Fediverse reader that pointed this site out for me!!...thank you lemon❤️️) sheds in CentreCo, near Philly and in MonroeCo are experiencing increases in tested SARS2 material.: https://ibb.co/BgDtfH0

On WastewaterSCAN, levels are still HIGH nationally for SARS2, RSV, and Norovirus (which is the "24hr stomach thing" from tainted surfaces/food). Make sure your utensils and eating places are cleaning things properly...this stuff's just gross 🤢: https://ibb.co/LSnpD2j

We are not out of the woods yet with this illness season. PLEASE practice some source control as this blazing fast JN.x.y clan takes over and can push numbers way up if we get hit with multiple very fit variants at once.
NOWCAST

The latest NOWCAST from CDC is out. JN.1 estimated at 85% of cases this week! 👀🚀👀🚀👀🚀: https://ibb.co/LS53WZH

Lots of junk out there and JN.x.y is some seriously fast business. Please  doooooooooo the source control  and we can prevent life, learning, and financial loss and have an easy transition into spring! 😷😷😷

(And be careful out there today too ❄️❄️❄️)

#JN1Eleven

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Good Morning SARS2PAians!

I hope you have a restful and powerful holiday today! ✊

Thre's not much new info out today. No Tableau stuff, no wastewater.

__________
CDC

CDC has released new per-county information, though.

The new hospital admits map has improved quite a bit for now, the post-holiday pre-school timeslot. Cases are still substantially increasing in the counties along south of I-80, and north up to Potter and McKean Cos.: https://ibb.co/zSCd72n

Also in Crawford, Franklin and Fulton Cos.

The map showing inpatient beds has gotten only slightly better, still a LOT of counties showing substantial and high increases.: https://ibb.co/ZxS1yYN

A direct result of waning immunity considering most people not getting current vaccines...XBB or even their bivalents from last year.

Substantial increases east of Potter Co, east of Luzerne Co, in Berks, and east of Juniata.

ICU bed occupation near the Philly area and surrounding counties has considerably lessened since last update where this area in particular was experiencing high levels.: https://ibb.co/n8vsDst

Now everywhere else but Philly and surrounding counties are showing substantial and high levels. Again, those counties are the same already mentioned...East of Juniata, east of Luzerne, Berks, and along the western half of the NY border counties. Also in Mercer Co.

C19 Emergency Dept visits are nationwide on the low side except here in the Northeast.: https://ibb.co/mbdkxDq

Unfortunately, as of Jan.11th, there have been 1,026 deaths from Covid-19 in PA in the past 3 months. (PLEASE NOTE this number keeps rising monthy.): https://ibb.co/xmjvw2d

PA, and in fact the majority of states, are in the highest CDC percentage category of states with COVID deaths in a 3 month roling period.

__________
JN.1 News

Along with 11 NYC public hospitals, mask mandates have returned to NYC EMS for their fire/ambulance emergency services.: https://www.msn.com/en-us/health/other/mask-mandate-returns-for-fdny-fire-ambulance-personnel-amid-rise-in-covid-other-viruses/ar-AA1mVNAu

China is issuing stern warnings about JN.1, but I want to draw attention to the last paragraph of this article in particular: https://news.cgtn.com/news/2024-01-14/China-warns-on-possible-rebound-of-COVID-19-JN-1-subvariant-1qmE7pROeGY/p.html

""High-risk groups like pregnant women, children and the elderly should prioritize annual influenza vaccination and maintain healthy habits," Wang advised. He further stressed the importance of understanding that contracting one type of respiratory illness does not guarantee immunity against others in the short term."

Please, folks, keep up with all available respiratory vaccinations, not just COVID.

Encourage children to mask up with quality respirators when they go back to school. If we are cautious until the Spring it's going to save us going through some things in the long run!! 😷😷😷

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater

Good Day Fediverse, SARS2PAians!

A bit late for me to mirror this on the Fediverse (sorry), but here's the 1/12/2024 update!

There's no new CDC hospitalization data today.

__________
VOCs

Nationally, JN.1 solidly in the lead with over 27% leaderboard share in random sequencing.: https://ibb.co/7QdWsxz

In PA, HV.1 in the lead...but not by much, 16% vs. 17%. Weird.: https://ibb.co/rd18RCq

But, I would think that if JN.1 isn't blazing fast here like in other places, especially being close to densely infected metro areas like NY and Jersey, we're doing something right.

We're wearing respirators, keeping close watch of social contacts, and keeping the air clean.

Everyone can snd should practice SOME form of source control. IT WORKS! 😎

IN NY/NJ, JN.1 at 37% of share.: https://ibb.co/tDsZqTS

JN.1.4 is one of a few upcoming variants that have potential to compete with JN.1 but will most likely not actually take over. The JNs will probably just take over more and more of the share from everything else below it.

There's nothing that can take over JN.1.

Yet.

___________
Wastewater

Nationally, SARS2 wastewater is starting to level off a bit.: https://ibb.co/nMgxSvz

Don't get comfortable, the kids still have to go back to school.: https://ibb.co/FnFLrzc

Regionally, the Northeast is still going slightly up but the growth is slowing. The rest of the regions are stable and not rising.: https://ibb.co/2YV5D0Z

In PA, 4/11 sheds reporting naything close to current, and those sheds are all going vertical. The small drop at the end is usually due to incomplete data and not an actual drop in material.: https://ibb.co/2YV5D0Z

If you look at the cumulative data through this whole thing, you can see easily that in BucksCo and in the other current data sheds (Lackawanna, Luzerne, MontCo) that this is the second highest rise in material throughout the pandemic.

BucksCo: https://ibb.co/DCCGwrz

Other sheds: https://ibb.co/brCcRQF

And the concentration is VERY HIGH at over (EDIT:) 2000m/L.

This rise is NOT due to persistence in the gut and extreme shedding through GI issues, but rather due to actual reinfections.: https://ibb.co/5KK6LR9

 Maria Van Kekhove, a director at the WHO, tweeted:

"What is driving circulation is an evolving virus (now JN.1 represents >50% of sequences shared for global analysis) that is reinfecting people in all countries, limited or no public health and social measures used to limit exposure, and many other factors"

__________
CDC

The most current At-A-Glance graphic still has the country trending the wrong way.: https://ibb.co/RbGdvDv

Most states are in HIGH, VERY HIGH or EXTREME levels of Influenza-Like Illnesses (ILI), a combo of a bunch of things like COVID, FluA, FLuB, parainfluenza, colds, etc.: https://ibb.co/L1n896y

Please take caution now because this could make us all go through some things when these kids go back to school.

Wear a respirator, have those kids wear them.  

Clean the air, use those CR boxes/HEPA filters!  

Keep track of social contacts  

Ventilate when possible/weather permits  

Keep unnecessary travel to a minimum    (<---i love this parrot LOL)

If we use caution now the back-to-school fallout won't disrupt the health care system, and we'll all be much happier! 😷😷😷

#covid #Covid19 #SARS2PA #CDC #CovidIsNotOver #Pennsylvania #PA #BA286 #JN1 #HV1 #WearAMask #CleanTheAir #VaccinesSaveLives #Flu #Influenza #RSV #Wastewater