Victoria Stuart 🇨🇦 🏳️‍⚧️Jun 27, 2024

Infection, immunity has a strong genetic component; individual genetic variants among population affect susceptibility, response to pathogens.

Scientists closing in on why some people never get COVID; could help w. future vaccines
A new study identified a specific gene in people who didn't get infected
https://www.cbc.ca/news/health/never-covid-1.7248039

Human SARS-CoV-2 challenge uncovers local and systemic response dynamics
https://www.nature.com/articles/s41586-024-07575-x

#COVID19 #COVID #SARSCoV2 #genetics #GeneticVariation #immunity #HLADQA2

Scientists closing in on why some people never get COVID. That could help with future vaccines | CBC News

Scientists describe high activity of a specific gene in volunteers who didn't get infected when exposed to COVID-19 on purpose. They hope better understanding early immune responses could help develop nasal spray forms of vaccines for the coronavirus.

CBC
AuscandocJun 19, 2024
Human #SARSCoV2 challenge uncovers local and systemic response dynamics | Nature https://www.nature.com/articles/s41586-024-07575-x “observed that the #interferon response in blood preceded the nasopharyngeal response. Moreover, #nasopharyngeal immune infiltration occurred early in samples from individuals with only transient infection and later in samples from individuals with sustained infection. High expression of #HLADQA2 before inoculation was associated with preventing sustained infection” #COVID
Human SARS-CoV-2 challenge uncovers local and systemic response dynamics - Nature

A human SARS-CoV-2 challenge study in individuals without previous exposure to the virus or vaccines provides detailed profiles of local and systemic epithelial and immune cell response dynamics over time and infection status.

Nature