Immune escape of Hepatitis B virus (HBV): based on >500 HBV genomes and clinical data we could discover many mutations by which the virus can escape immune recognition. We also show how the adaptation of HBV to the immune system changes over the course of the infection. The key tool in this collaboration of virologists and bioinformaticians was our #Bayesian HAMdetector method.

https://doi.org/10.1016/j.jhep.2024.10.047

https://github.com/HAMdetector/Escape.jl

#infections #HBV #immunity #medicine #Bayes #HAMdetector

HBV shows different levels of adaptation to HLA class I-associated selection pressure correlating with markers of replication

Immune responses by CD8 T cells are essential for control of HBV replication. Although selection of escape mutations in CD8 T cell epitopes has been p…