The GPR174 modulates #immune homeostasis by engaging distinct #Gproteins. This study shows that hydration-mediated interactions stabilize the active-state conformation of #GPR174 & reshape its intracellular cavity by enabling selectivity @PLOSBiology https://plos.io/4dsN81j

Modeling & experimental analyses of a Golgi-localized GTPase circuitry that allows cancer cells to achieve self-sufficiency in growth factor signaling ➡️ http://bit.ly/41DK7Dj
P Rangamani & P Ghosh, UCSD
#Gproteins #CellSignaling #EGFR #SystemsBiology