michaelDec 4

4-Dec-2025
researchers identify the #brain #enzyme that drives #nicotine #addiction and #smoking dependence
Researchers uncover how overlooked #glial cells regulate nicotine-dependent behavior, pointing toward future smoking cessation-related research

^^ #preclinical research on #rats still but interesting. What ever the mechanism for nicotine addiction is, I don't have it, so I'm kind of curious about it.

https://www.eurekalert.org/news-releases/1108332

#science #publicHealth #neuroscience

Pusan National University researchers identify the brain enzyme that drives nicotine addiction and smoking dependence

Nicotine addiction remains one of the most persistent global health challenges, yet the cellular mechanisms underlying it are less explored. Now, researchers have discovered that astrocytes, glial cells in the brain thought to play only a passive role, actively contribute to the brain changes triggered by repeated nicotine exposure. The findings provide insights into nicotine-induced changes in the brain by an enzyme that regulates a key glutamate-related pathway linked to sensitized behavior.

EurekAlert!
Fabrizio MusacchioJun 30, 2025

Recently, we discussed this insightful paper by Squadrani et al (2024) in our #JournalClub. It explores how #astrocytes enhance #SynapticPlasticity during #ReversalLearning by modulating D-serine levels, providing a #biophysical basis for dynamic #LTP thresholds. The findings suggest astrocytic signaling is crucial for #AdaptiveLearning, linking #glial activity to #behavioral flexibility. Here’s a summary from our JC:

🌍 https://www.fabriziomusacchio.com/blog/2025-06-29-astrocyte_enhance_plasticity/
📝 https://doi.org/10.1038/s42003-024-06540-8

#CompNeuro #Neuroscience

Giuseppe MichieliJun 21, 2025
#Glial cells promote #infection by #neurotropic #Influenza A viruses in vitro, https://etidiohnew.blogspot.com/2025/06/glial-cells-promote-infection-by.html
#Glial cells promote #infection by #neurotropic #Influenza A viruses in vitro

Alan LewisMar 25, 2024

MEDICAL SCIENCE DISCOVERY
MYELIN REPAIR

March 25, 2024
Scientists identify a key driver of myelin repair

by Nicholas Weiler, Stanford University

https://medicalxpress.com/news/2024-03-scientists-key-driver-myelin.html

:

#glial #glialcells #medicalscience #medicalsciencenews #miguelgarcia #multipleschlerosis #myelin #myelination #myelinrepair #myelinsheath #neurodegenerative #neurodegenerativediseases #nicholasweiler #oligodentrocytes #proceedingsofthenationalacademyofsciences #sciencenews #serumresponsefactor #srf #stanforduniversity #structuralgenesrf #taliram #wutsaineurosciencesinstitute

:::

Scientists identify a key driver of myelin repair

New research from scientists at the Wu Tsai Neurosciences Institute at Stanford University has identified a key driver of myelination, the formation of protective fatty sheaths around nerve fibers.

Medical Xpress
Kara FinanceFeb 28, 2024

Word Search Puzzle 728

Word List : #akkadist #eridanid #johannes #cantrip #overheat #conidium #bursa #elijah #anaunter #korunas #provine #cearin #wardapet #whopper #rabbish #glial #opsonoid #vespetro

http://karafinance.com/2024/02/27/word-search-puzzle-728/

Word Search Puzzle 728

Word List : #akkadist #eridanid #johannes #cantrip #overheat #conidium #bursa #elijah #anaunter #korunas #provine #cearin #wardapet #whopper #rabbish #glial #opsonoid #vespetro

Kara Finance
Show threadGiuseppe MichieliSep 15, 2023
''Histopathologic examination of #tissues sampled from the adult female showed multifocal #infiltration of the #meninges by numerous lymphoplasmacytic cells, which extended into the Virchow–Robin spaces, forming perivascular cuffing. Neuronal #necrosis associated with satellitosis and #glial nodules was commonly observed.''
Show threadSpaceflight 🚀Jun 16, 2023

#Flies 🦟 exposed to #μg conditions show behavioral and #neuronal deficits, #glial alterations, #oxidative damage, and #apoptosis https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01099-3

Glial cells : cells in the central nervous system (brain and spinal cord) and the peripheral nervous system https://en.wikipedia.org/wiki/Glia
Apoptosis : programmed cell #death ☠️ that occurs in multicellular organisms https://en.wikipedia.org/wiki/Apoptosis

#Spaceflight #microgravity

ReneeDec 5, 2022

Einstein 🦝 #raccoons 🤔

These critters have more #glial cells in their #hippocampus 🧠 (area for learning & memory); these cells guard against #inflammation & help #communication among #neurons (storing memories & underpinning complex behaviors).

More glial cells = more adaptive cognition.

Einstein’s brain had more glial cells than the brains 🧠 of average intelligence men.

Raccoons may be pests, BUT intelligent pests!!

#WSJ - 12.5.22 “Scientists Give Rowdy Raccoons a Reputation Makeover”