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Diana haussa les épaules pour se débarrasser de son t-shirt ample, de son short de pyjama et de sa culotte.

Researchers develop new way to safely insert gene-sized DNA into the genome

Genome editing-based therapies typically aim to treat disease by correcting underlying genetic mutations in patient’s cells. However, most genetic disorders are caused by dozens or even thousands of unique mutations spread across a gene; this diversity results in challenges of scale when it comes to developing customized therapies for many individuals. A more universal strategy could involve the precise insertion of an entire copy of a healthy gene into a specific location in the genome, which could, in principle, provide a single, widely applicable treatment for all patients irrespective of their mutation within that gene.   Taking a step towards developing genetic therapies at scale, researchers from Mass General Brigham and colleagues describe a novel, non-toxic approach for inserting gene-sized DNA in a study published in Nature.

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