PLOS BiologyMar 13, 2024
Diversity of somatostatin #GABAergic inhibitory interneurons. Study compares anatomical & physiological properties of 2 subtypes of #somatostatin #interneuron, finding key differences that may underlie their functionalities #PLOSBiology https://plos.io/3wRTXXD
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons

Somatostatin GABAergic inhibitory interneurons have important roles in neuroplasticity, learning and memory, but the functional roles of some subtypes are not well understood. Here, the authors compare the anatomical and physiological properties of two subtypes of somatostatin interneurons, finding key differences that could underlie their functionalities and providing essential information to model the hippocampal network.

Moritz NegwerFeb 13, 2024

Cool new #PNN paper: PNNs regulate excitatory input on PV+ cells (in NAc at least):

The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors
Hazlett et al., Biological Psychiatry 2024
https://doi.org/10.1016/j.biopsych.2024.02.003

#neuroscience #parvalbumin #GABAergic

PLOS BiologyFeb 1, 2024
GABAARs: not just inhibitory? This study of striatal spiny projection #neurons shows that #GABA is a state-dependent #neurotransmitter, and not simply an inhibitory one, suggesting a revision of the role of intrastriatal #GABAergic signaling #PLOSBiology https://plos.io/3SGKafq
GABAergic regulation of striatal spiny projection neurons depends upon their activity state

Synaptic transmission mediated by GABAA receptors in adult principal striatal spiny projection neurons can suppress ongoing spiking, but what is its effect on synaptic integration at sub-threshold membrane potentials? This study shows that GABA is a state-dependent neurotransmitter, and not simply an inhibitory neurotransmitter, suggesting a revision of the role of intrastriatal GABAergic signaling.

Moritz NegwerDec 7, 2023

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

PLOS BiologyMar 13, 2023
A network of #plasticity mechanisms: subcortical microstructural (#myelination) plasticity & cortical neurochemical (#GABAergic) plasticity interact via #thalamocortical connectivity to support optimized perceptual decisions @CambridgeABL #PLOSBiology https://plos.io/3YHNvdR
Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making

This multimodal brain imaging study reveals an interactive network of plasticity mechanisms: subcortical microstructural (myelination) plasticity and cortical neurochemical (GABAergic inhibition) plasticity interact through thalamocortical connectivity to support optimized perceptual decisions.

PLOS BiologyMar 13, 2023
A network of #plasticity mechanisms: subcortical microstructural (#myelination) plasticity & cortical neurochemical (#GABAergic) plasticity interact via #thalamocortical connectivity to support optimized perceptual decisions @CambridgeABL #PLOSBiology https://plos.io/3YHNvdR
Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making

This multimodal brain imaging study reveals an interactive network of plasticity mechanisms: subcortical microstructural (myelination) plasticity and cortical neurochemical (GABAergic inhibition) plasticity interact through thalamocortical connectivity to support optimized perceptual decisions.

PLOS BiologyMar 13, 2023
A network of #plasticity mechanisms: subcortical microstructural (#myelination) plasticity & cortical neurochemical (#GABAergic) plasticity interact via #thalamocortical connectivity to support optimized perceptual decisions @CambridgeABL #PLOSBiology https://plos.io/3YHNvdR
Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making

This multimodal brain imaging study reveals an interactive network of plasticity mechanisms: subcortical microstructural (myelination) plasticity and cortical neurochemical (GABAergic inhibition) plasticity interact through thalamocortical connectivity to support optimized perceptual decisions.

PLOS BiologyJan 7, 2023
Info from #somatosensory nerves can be actively modified at the #DorsalRootGanglion. This study reveals the existence of tonic & dynamic #GABAergic filtering of action potentials traveling through the #DRG; implications for #PainRelief #PLOSBiology https://plos.io/3VSJFNo
Dorsal root ganglia control nociceptive input to the central nervous system

Information transmitted along the peripheral somatosensory nerves can be actively modified at the dorsal root ganglion (DRG). This study demonstrates the existence of tonic and dynamic GABAergic filtering of action potentials traveling through the DRG, with therapeutic implications for pain relief.

PLOS BiologyJan 6, 2023
Info from #somatosensory nerves can be actively modified at the #DorsalRootGanglion. This study reveals the existence of tonic & dynamic #GABAergic filtering of action potentials traveling through the #DRG; implications for #PainRelief #PLOSBiology https://plos.io/3VSJFNo
Dorsal root ganglia control nociceptive input to the central nervous system

Information transmitted along the peripheral somatosensory nerves can be actively modified at the dorsal root ganglion (DRG). This study demonstrates the existence of tonic and dynamic GABAergic filtering of action potentials traveling through the DRG, with therapeutic implications for pain relief.

PLOS BiologyJan 6, 2023
Info from #somatosensory nerves can be actively modified at the #DorsalRootGanglion. This study reveals the existence of tonic & dynamic #GABAergic filtering of action potentials traveling through the #DRG; implications for #PainRelief #PLOSBiology https://plos.io/3VSJFNo
Dorsal root ganglia control nociceptive input to the central nervous system

Information transmitted along the peripheral somatosensory nerves can be actively modified at the dorsal root ganglion (DRG). This study demonstrates the existence of tonic and dynamic GABAergic filtering of action potentials traveling through the DRG, with therapeutic implications for pain relief.