#AntibioticResistance is a growing problem for
#Streptococcal infections. @motile_microbe &co show that disrupting fermentation with
#Fomepizole increases sensitivity of S. pneumoniae to
#antibiotics, incl in vivo
#pneumonia model validation
#PLOSBiology https://plos.io/3mYWTwx 
Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease
Antibiotic resistance is a increasingly important problem for Streptococcus pneumoniae infections. This study shows that blocking fermentation and disrupting redox balance increases the sensitivity of this bacterium to antibiotics, including validation in vivo using a pneumonia model with antibiotic resistant pneumococci.
#AntibioticResistance is a growing problem for
#Streptococcal infections. @motile_microbe &co show that disrupting fermentation with
#Fomepizole increases sensitivity of S. pneumoniae to
#antibiotics, incl in vivo
#pneumonia model validation
#PLOSBiology https://plos.io/3mYWTwx Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease
Antibiotic resistance is a increasingly important problem for Streptococcus pneumoniae infections. This study shows that blocking fermentation and disrupting redox balance increases the sensitivity of this bacterium to antibiotics, including validation in vivo using a pneumonia model with antibiotic resistant pneumococci.
#AntibioticResistance is a growing problem for
#Streptococcal infections. @motile_microbe &co show that disrupting fermentation with
#Fomepizole increases sensitivity of S. pneumoniae to
#antibiotics, incl in vivo
#pneumonia model validation
#PLOSBiology https://plos.io/3mYWTwx Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease
Antibiotic resistance is a increasingly important problem for Streptococcus pneumoniae infections. This study shows that blocking fermentation and disrupting redox balance increases the sensitivity of this bacterium to antibiotics, including validation in vivo using a pneumonia model with antibiotic resistant pneumococci.
PLOS Biology