@sethmelton
Salamander
I very much enjoyed the MSX version of Salamander; it's notably different from the Lifeforce version that was released for the NES.
I recommend using this patch set https://github.com/bladeba/MSX/tree/master/Enhanced%20Games/Salamander%20-%20enhanced which adds smooth scroll, SCC voice sample support, additional colour schemes. Play online here: https://www.file-hunter.com/MSX/?id=salamander-enhanced
Vampire Killer
Vampire Killer also has significantly different gameplay than its Castlevania version for the NES. While it has fixed screens rather than smooth scrolling, it adds more of an adventure element to it, with needing to find skeleton keys to advance to the next levels, and bronze keys to open chests, and a couple of weapon changes.
(Though there's a fan-made patch that turns VK more into a Castlevania experience: https://www.msx.org/news/en/vampire-killer-to-castlevania-msx2-patch)
There are a couple of community patches for this one too, such as SCC sound chip support, smoother gameplay JoySNES support, etc. You can play a fully patched version of it here: https://www.file-hunter.com/MSX/?id=vampirekillerscc
Various other patched versions can be found here: https://download.file-hunter.com/Games/MSX2/ROM/
Other games
I'm running out of time for more in-depth recommendations; might edit them in later, but here are a couple of quick ones:
#FiXatoRecommends #MSX #MSX2 #games #gaming