🚨 New hypothesis: One mechanism links schizophrenia, depression & PTSD: collapse of excitability margin (ΔVmargin) in ventral CA1.

🎥 9-min explainer video: https://www.youtube.com/watch?v=DWbEN-F5ML

🔗 Full preprint: https://osf.io/preprints/osf/e4cwb_v3

#Neuroscience #Psychiatry #MentalHealth #Schizophrenia #Depression #PTSD #OpenScience #FediSci

🚨 New hypothesis: a unifying mechanism for #Schizophrenia #Depression & #PTSD and other diseases - a dangerously narrowed excitability margin in hippocampal CA1.
🎥 Video explainer: https://www.youtube.com/watch?v=DWbEN-F5MLY

📄 Preprint: https://osf.io/preprints/osf/e4cwb_v3

#Neuroscience #Psychiatry #MentalHealth #OpenScience #Brain #Research #Neurobiology #FediSci #autism #alzheimer #bipolar #health

🚨 New hypothesis: One mechanism links schizophrenia, depression & PTSD: collapse of excitability margin (ΔVmargin) in ventral CA1.

https://www.youtube.com/watch?v=DWbEN-F5MLY

#Neuroscience #Psychiatry #MentalHealth #Schizophrenia #Depression #PTSD #OpenScience #FediSci

🚨 New preprint: One mechanism links schizophrenia, depression & PTSD: collapse of excitability margin (ΔVmargin) in ventral CA1.
Chronic stress (–11.3 mV), hot-spot recall (–3.2 mV) + risk factors (alleles, psychoactives, infections, diet, microplastics) converge. Once ΔVmargin <5 mV, engram valence → phenotype (fear→SZ, sadness→DEP, trauma→PTSD).

📄 https://doi.org/10.31219/osf.io/e4cwb_v2
#Neuroscience #Psychiatry #MentalHealth #Schizophrenia #Depression #PTSD #OpenScience #FediSci

🚨 New preprint: One mechanism links schizophrenia, depression & PTSD: collapse of excitability margin (ΔVmargin) in ventral CA1.
Chronic stress (–11.3 mV), hot-spot recall (–3.2 mV) + risk factors (alleles, psychoactives, infections, diet, microplastics) converge. Once ΔVmargin <5 mV, engram valence → phenotype (fear→SZ, sadness→DEP, trauma→PTSD).

📄 https://doi.org/10.31219/osf.io/e4cwb_v2

#neuroscience #psychiatry #schizophrenia #depression #PTSD #brain #research #openScience #FediSci #MentalHealth