PLOS Biology#Hyperglycemia activates glucose sensing & feeding behavior in #hypothalamus via CSF. @katterineSalaz2 @FranciscoNuala2 &co show that raised CSF glucose induces SCO-spondin & Wnt5a release, controlling ciliary beating in #EpendymalCells. #PLOSBiology https://plos.io/3Rsb8qV
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose sensing and feeding behavior in the hypothalamus. This study shows that raised CSF glucose levels induce release of SCO-spondin and Wnt5a, controlling ciliary beating in the ependymal cells.