My second @preLights post is all about “LaBeRling” ER membrane contact sites (ER MCS)! Established methods for labelling ER MCS can promote contact sites and stabilise/extend already established sites.

The @roylelab have found the ER resident Lamin B receptor may offer a anchor for chemical heterodimerization to label a variety of ER MCS at particular times, without affecting their properties.

#EndoplasmicReticuium #Microscopy #MembraneContactSites #preprint

#preLight https://prelights.biologists.com/highlights/non-disruptive-inducible-labeling-of-er-membrane-contact-sites-using-the-lamin-b-receptor-v2/

Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor - preLights

Time to “LaBeRl” your contacts: The Royle lab develop a method for labelling ER membrane contact sites without changing the number, extent, or distance of the contacts.

preLights