ICYMI, it was a pleasure to interview Nobel-prize winning immunologist Tasuku Honjo about the story behind his lab's discovery of PD1, a classic @embojournal paper from 1992.
π§ #EMBOPodcast #EMBOJournal #Immunology #immunotherapy #checkpointinhibitors #HistoryOfScience
https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/
A paper that I was not aware of in @embojournal that scientific editor @HVodermaier mentioned in the #telomerase independent immortalisation discussion on the latest #EMBOPodcast episode is the finding from Lackner, Karlseder et al in #EMBOJournal 2012 of a very interesting ALT system in #Celegans
π§ to the episode
https://www.embo.org/podcasts/alternative-immortality/
Read the paper (#OpenAccess)
https://www.embopress.org/doi/full/10.1038/emboj.2012.61
The latest episode of the EMBO Podcast #EMBOPodcast is out π§
I spoke with Roger Reddel & Tracy Bryan at Sydney's Children's Medical Research Institute about their classic 1995 @embojournal paper describing #telomerase independent #telomere lengthening in immortalised cell lines. It challenged conventional wisdom at the time - and it was Bryan's PhD project, quite a way to get started in science.
@miguelgf provided some perspective on the work and its enduring significance and editor @HVodermaier explained #EMBOJournal's interest in studies with striking findings that may not provide a full mechanistic description.
You can listen to "ALTernative immortality" at the link below or on your preferred podcast app. Special thanks to Igor Jukic & audio producer extraordinaire @marcoantonio
Nice cover illustration by Felipe Serrano (www.illustrative-science.com) For Cabral-Miranda et al's "Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging" in the #EMBOJournal
"Here, we establish microglia as a new cellular component of the sleep homeostasis circuit. Using quantitative phosphoproteomics of the mouse frontal cortex, we demonstrate that microglia-specific deletion of TNFΞ± perturbs thousands of phosphorylation sites during the sleep period. Substrates of microglial TNFΞ± comprise sleep-related kinases such as MAPKs and MARKs, and numerous synaptic proteins, including a subset whose phosphorylation status encodes sleep need and determines sleep duration."
Fatih Demir
Thiago Carvalho