#Lineage-specific #pathogenicity, immune #evasion, and virological #features of #SARS-CoV-2 #BA286 / #JN1 and #EG51 / HK.3

Source: Nature Communications, AbstractSARS-CoV-2 JN.1 with an additional L455S mutation on spike when compared with its parental variant BA.2.86 has outcompeted all earlier variants to become the dominant circulating variant. Recent studies investigated the immune resistance of SARS-CoV-2 JN.1 but additional factors are speculated to contribute to…

https://etidioh.wordpress.com/2024/10/09/lineage-specific-pathogenicity-immune-evasion-and-virological-features-of-sars-cov-2-ba286-jn1-and-eg51-hk-3/

Immunogenicity and #efficacy of #XBB15 rS #vaccine against the #EG51 #variant of #SARS-CoV-2 in Syrian #hamsters, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00528-24?af=R

Thus, based on these study results, the protein-based XBB.1.5 vaccine is immunogenic and increased the breadth of protection against the Omicron EG.5.1 variant in the Syrian hamster model.

Increased #pathogenicity {in animal models} and #transmission of #SarsCoV2 #Omicron #XBB19 #sublineage, including #HK3 and #EG51, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.10.598324v1?rss=1

HK.3 and EG.5.1 exhibited greater pathogenicity than XBB.1.9.1 and BA.2 in H11-K18-hACE2 #hamsters. Our studies provide insight into the newly emerging #pathogens HK.3 and EG.5.1.

Evaluating #Humoral #Immunity Elicited by #XBB15 Monovalent #COVID19 #Vaccine, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/6/24-0051_article

We report boosting of #IgG (2.1×), #IgA (1.5×), and total IgG/A/M (1.7×) targeting the #spike receptor-binding domain and neutralizing titers against WA1 (2.2×), XBB.1.5 (7.4×), #EG51 (10.5×), and #JN1 (4.7×) variants.

Virological characteristics of the #SARS-CoV-2 #BA286 #variant, Cell: https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(24)00005-2?rss=yes

• BA.2.86 is more transmissible than the currently predominant #EG51
• The sensitivity of BA.2.86 to #antiviral #drugs is comparable to that of EG.5.1
• The #replication efficiency of BA.2.86 in vitro and in vivo is lower than that of EG.5.1
• In hamsters, BA.2.86 is less #pathogenic than EG.5.1 and the parental BA.2

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