Giuseppe MichieliA rapid #review of the avian #influenza #PB2 #E627K #mutation in #human infection studies, https://etidiohnew.blogspot.com/2025/04/a-rapid-review-of-avian-influenza.html
''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''
Characterization of #H5N1 avian #influenza virus isolated from #bird in #Russia with the #E627K mutation in the #PB2 protein
Source: Scientific Reports, AbstractCurrently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic avian influenza A(H5N1) clade 2.3.4.4b reassortant viruses have become predominant in the world and caused multiple infections in mammals. It was shown that some of…
Characterization of #H5N1 avian #influenza virus isolated from #bird in #Russia with the #E627K mutation in the #PB2 protein
Source: Scientific Reports, AbstractCurrently A(H5Nx) avian influenza viruses are globally widespread and continue to evolve. Since their emergence in 2020 novel highly pathogenic avian influenza A…
#Outcome of #H5N1 clade 2.3.4.4b virus #infection in #calves and lactating #cows, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.08.09.607272v1
Adaptive #mutation #PB2 #E627K emerged after intramammary #replication of H5N1 euDG. Our data suggest that in addition to H5N1 B3.13, other HPAIV H5N1 strains have potential to replicate in #udder of cows & that #milk & milking procedures, rather than respiratory spread, are likely the primary routes of H5N1 #transmission between cattle.
The #virus #sequences are HA clade 2.3.4.4b HPAI A(#H5N1) with each individual gene segment closely related to viruses detected in dairy #cattle available from USDA testing in Texas.
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both cattle and #human sequences maintain primarily avian genetic characteristics and for the most part lack changes that would make them better adapted to infect #mammals. The genome for the human isolate had one change (#PB2 #E627K) that is known to be associated with viral adaptation to mammalian hosts
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both cattle and #human sequences maintain primarily avian genetic characteristics and for the most part lack changes that would make them better adapted to infect #mammals. The genome for the human isolate had one change (#PB2 #E627K) that is known to be associated with viral adaptation to mammalian hosts
Detection of clade 2.3.4.4 highly pathogenic avian #influenza #H5 viruses in healthy wild #birds in the Hadeji-Nguru #wetland, #Nigeria 2022, https://onlinelibrary.wiley.com/doi/10.1111/irv.13254
-- Whole-genome characterization of the viruses reveals the presence of #mammalian adaptive #marker #E627K in two Afro-tropical resident aquatic #ducks. This has zoonotic potential.
Raj Rajnarayanan 
Key mutations among the #AvianInfluenza sequences isolated from #Cats uploaded to #EpiFlu @gisaid from #Poland | Analysis using #FluServer tool.
Interesting #PB2 mutations: #E627K (Mammalian Adaptation Signature) and #K526R (Enhances E627K)
''The XL virus had similar
#mammalian #adaptations to #human-originated #H7N9 viruses, such as the polymerase basic protein 2 (#PB2) Glu-to-Lys mutation at position 627 (#E627K) mutation, but differed from avian-originated H7N9 viruses''
#mammalian #adaptations to #human-originated #H7N9 viruses, such as the polymerase basic protein 2 (#PB2) Glu-to-Lys mutation at position 627 (#E627K) mutation, but differed from avian-originated H7N9 viruses''