PLOS BiologyAug 15, 2024
#Pancreatic ductal #adenocarcinoma (PDAC) is a deadly #cancer. @RoLiefke &co show that chromatin regulator SAMD1 represses EMT-related genes, inhibiting cellular migration, and is downregulated during #PDAC progression by #E3ligase FBXO11 #PLOSBiology https://plos.io/4crkx94
SAMD1 suppresses epithelial–mesenchymal transition pathways in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer usually only detected at an advanced and metastatic state. This study shows that the chromatin regulator SAMD1 represses genes related to the epithelial-mesenchymal transition (EMT), thereby inhibiting cellular migration, and is downregulated during PDAC progression by the E3 ligase FBXO11.

PLOS BiologyMay 23, 2024
Targeted protein degradation #PROTAC is a promising avenue for drug development. This study shows that alkenyl oxindole compounds act as novel #E3ligase ligands & recruit the CRL4-DCAF11 E3 #ubiquitin ligase complex for substrate degradation #PLOSBiology https://plos.io/3WV1U9q
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation

Targeted protein degradation strategies are promising avenues for drug development, but it is important to broaden the toolbox of E3 ligases that can be engaged. This study shows that alkenyl oxindole compounds act as novel E3 ligase ligands and recruit the CRL4-DCAF11 E3 ubiquitin ligase complex for substrate degradation.

Cell Chemical BiologyNov 20, 2023
Online now! Genetic retargeting of E3 ligases to enhance CAR T cell therapy by @isabel_c_lane, @janlabmgh, and colleagues at @harvardmed @MassGeneralNews @broadinstitute and others https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00386-0?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #chembiol #CART #E3Ligase
Cell Chemical BiologyNov 16, 2023
The November Issue of @CellChemBiol is Online! Read it at: https://www.cell.com/cell-chemical-biology/current?utm_source=dlvr.it&utm_medium=mastodon #chemicalbiology #GPCR #RAF #STING #SARSCOV2 #ASO #PDL1 #HDAC #indoxylsulfate #E3ligase #UPS10 #targetID #luciferin #forwardgenetics
Hao YinDec 29, 2022

Stabilizing FOXF1 to treat #AlveolarCapillaryDysplasia

Chemical screening->TanFe
⏬Ubiquitination of FOXF1 via⏬binding to #E3Ligase HECTD1/SHPRH/NEURL1B etc->

Restoring Lung #Angiogenesis of Foxf1+/-🐭

Dr. Vladimir Kalinichenko lab Am J Respir Crit Care Med 2022
https://www.atsjournals.org/doi/10.1164/rccm.202207-1332OC

How FOXF1 impacts #EndothelialCell #Angiogenesis?

As a transcription factor for S1PR1 & VE-Cad😎

An excellent story from Dr. Vladimir Kalinichenko lab @scisignal 2016👇

FOXF1 maintains endothelial barrier function and prevents edema after lung injury

https://www.science.org/doi/10.1126/scisignal.aad1899

Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, due to FOXF1 heterozygous mutation, has very complex Lung & ex-Lung vascular phenotypes

A few reads🤠

https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-020-00972-6

https://www.nature.com/articles/jp201494

https://www.nature.com/articles/ejhg2012171

https://www.jpeds.com/article/S0022-3476(04)00647-X/fulltext

Novel FOXF1-Stabilizing Compound TanFe Stimulates Lung Angiogenesis in Alveolar Capillary Dysplasia | American Journal of Respiratory and Critical Care Medicine | Articles in Press

Hao YinNov 28, 2022

K63 #Ubiquitination of #YAP by SKP2 #E3Ligase⏫its nuclear import🤠

Synergized with mTORC1-PERK-ATF4 axis in renal #Cystogenesis🐭#JuvenileCysticKidney #Ciliopathy

A #CellCycle-specific regulation of YAP?😆

Dr. Andrew Karaplis lab JCI 2022
https://www.jci.org/articles/view/153943

JCI - SCF-SKP2 E3 ubiquitin ligase links mTORC1-ER stress-ISR with YAP activation in murine renal cystogenesis