StructBiolCommunicationsMar 10, 2025
The crystal structure of the murine TRIM21 PRYSPRY domain in complex with suramin was solved at 1.3 Å resolution. This video shows the conformational changes upon suramin binding. #TRIM21 #E3Ligases #CrystalStructure https://doi.org/10.1107/S2053230X25000913
LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

This communication describes the crystal structure of TRIM21 in complex with suramin, providing new opportunities to target this E3 ligase.

Acta Crystallographica Section F