CITO GreenhouseJul 19, 2025

Molecular Glue of the Brain: Cell Adhesion Molecules and Synaptic Stability

#Neuroscience #BrainScience #Synapses #NeuronalCircuits #Neuroplasticity #ExcitatoryInhibitoryBalance #DendriticSpines #ExtracellularMatrix #Interneurons #CognitiveHealth #Neurobiology #BrainDevelopment #NeuralConnections #Neuropsychiatry #BrainFunction

https://youtube.com/shorts/dz-Wr8VAww0?feature=share

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The-14Jul 6, 2024
Nanoscopic motor proteins in the brain build the physical structures of memory
#Science #Brain #Neuroscience #Memory #BrainResearch #Neurology #Neurons #Nanotechnology #MotorProteins #Biology #DendriticSpines #Learning #Research
https://the-14.com/nanoscopic-motor-proteins-in-the-brain-build-the-physical-structures-of-memory/
PLOS BiologySep 1, 2023
#DendriticSpines contain a specialized ER, required for Ca2+ signaling, spine enlargement & #SynapticPlasticity. @yipinghsueh &co show that KLHL17 & SYNPO control the synaptic distribution of the ER, and so regulate synaptic plasticity #PLOSBiology https://plos.io/45PMrbR
Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus

Dendritic spines contain a specialized form of endoplasmic reticulum, the spine apparatus, required for local calcium signaling, dendritic spine enlargement and synaptic plasticity. This study shows that KLHL17 and SYNPO, two autism-related F-actin-associated proteins, control the synaptic distribution and clustering of the endoplasm reticulum and ultimately regulate synaptic plasticity.