Nueva opción de tratamiento para el trastorno por #DéficitDeAtención
Peces zebra mutados para mostrar conductas típicas del #TDAH respondieron con estimulantes típicos (#Metilfenidato y #anfetaminas ) y con #Amlodipino
Ratones y ratas también respondieron al #calcioantagonista
En humanos se estudiaron expedientes, y las conductas compatibles con #TDAH eran menos frecuentes en los que recibían Amlodipino por otro diagnóstico
#ADHD #Dopamine #CalciumChannelBlockers
https://www.nature.com/articles/s41386-025-02062-x
Validation of L-type calcium channel blocker amlodipine as a novel ADHD treatment through cross-species analysis, drug-target Mendelian randomization, and clinical evidence from medical records - Neuropsychopharmacology
ADHD is a chronic neurodevelopmental disorder that significantly affects life outcomes, and current treatments often have adverse side effects, high abuse potential, and a 25% non-response rate, highlighting the need for new therapeutics. This study investigates amlodipine, an L-type calcium channel blocker, as a potential foundation for developing a novel ADHD treatment by integrating findings from animal models and human genetic data. Amlodipine reduced hyperactivity in SHR rats and decreased both hyperactivity and impulsivity in adgrl3.1−/− zebrafish. It also crosses the blood-brain barrier, reducing telencephalic activation. Crucially, Mendelian Randomization analysis linked ADHD to genetic variations in L-type calcium channel subunits (α1-C; CACNA1C, β1; CACNB1, α2δ3; CACNA2D3) targeted by amlodipine, while polygenic risk score analysis showed symptom mitigation in individuals with high ADHD genetic liability. With its well-tolerated profile and efficacy across species, supported by genetic evidence, amlodipine shows potential to be refined and developed into a novel treatment for ADHD.
Día mundial del Trastorno de Déficit de Atención e Hiperactividad o el TDAH - Somosdisc@
Cada 13 de julio se celebra el día Internacional del Trastorno de Déficit de Atención e Hiperactividad, o el TDAH, que afecta al 4%
Aurianne Or
CDCastillo
Somosdisca 