Compartmentalized #cytokine #networks and systemic immune remodeling in #bovine mammary #H5N1 #infection.

Shining New Light on How Cytokines Manage Immune Response

A new set of tools allows researchers to tag cells that receive signals from immune molecules called cytokines.

#Cytokine Regulation of #Human #Antibody Responses to #Influenza #Vaccines

Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries

The mechanistic understanding of the complex between ALK kinase and its cytokine ligand ALKAL2 has been complicated by reports of diverse stoichiometries (2:1 vs 2:2). This study reanalyzes cryo-EM data originally interpreted as showing a 2:2 ALK-ALKAL2 complex, revealing that the dataset includes a population with a novel 2:1 stoichiometry.

The Novel #H10N3 Avian #Influenza Virus Triggers Lethal #Cytokine #Storm by Activating Multiple Forms of Programmed Cell Death in Mammalian #Lungs

Modulation of #cytokeratin and #cytokine/chemokine expression following #influenza virus infection of differentiated #human #tonsillar epithelial cells

A strategy to design protein-based antagonists against type I cytokine receptors

Protein-based therapies have been developed to block cytokine signaling in a range of different diseases. These authors use a computational protein design approach to develop novel cytokine receptor antagonists and show that the designed proteins can inhibit G-CSFR activation in a cell model of acute myeloid leukemia.