Giuseppe MichieliEvolutionary Studies on the #Coxsackievirus A24 #Variants Causing Acute #Hemorrhagic #Conjunctivitis with Emphasis on the Recent #Outbreak of 2023 in #India, https://etidiohnew.blogspot.com/2025/03/evolutionary-studies-on-coxsackievirus.html
The Emergence of #Coxsackievirus A16 Subgenotype B1c: A Key Driver of the #HFMD #Epidemic in #Guangdong, #China, https://etidiohnew.blogspot.com/2025/02/the-emergence-of-coxsackievirus-a16.html
ETIDIoHSource: REGNUM, https://regnum.ru/news/3927294
{Excerpt}
(…) The press service of Rospotrebnadzor added that morning {entry check} filters in schools imply checking for signs of illness, including runny nose, cough, temperature, etc. If symptoms of illness are detected, the child is isolated from the group until he or she recovers.
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{#Russia, #Coxsackievirus [#HFMD] has sprad to several #schools and #kindergartens}
Source: REGNUM, {Excerpt} (...) The press service of Rospotrebnadzor added that morning {entry check} filters in schools imply checking for signs of illness, including runny nose, cough, temperature, etc. If symptoms of illness are detected, the child is isolated from the group until he or she recovers. (...) ____
StructBiolCommunicationsThe crystal structures of the 3C proteases from Coxsackievirus B3 and B4 will guide the design of 3C-targeting inhibitors with broad-spectrum properties #Coxsackievirus #CVB3 #CVB4 https://t.co/0bmNbUuDAq
Crystal structures of the 3C proteases from Coxsackievirus B3 and B4
The crystal structures of the 3C proteases from Coxsackievirus B3 and Coxsackievirus B4 were determined at 2.10 and 2.01 Å resolution, respectively. The structures reveal the presence of a typical chymotrypsin-like fold and a conserved catalytic triad, which are similar to those observed in 3C proteases from other enteroviruses.
PLOS Biology#RNAviruses mutate rapidly, but natural selection concentrates this variability. @bealro @RonGellerLab &co measure effects of >40,000 mutations across the #coxsackievirus B3 proteome, revealing significant variation within & between proteins #PLOSBiology https://plos.io/3W9SR23
Mapping mutational fitness effects across the coxsackievirus B3 proteome reveals distinct profiles of mutation tolerability
RNA viruses replicate with high mutation rates, but natural selection concentrates variability in a few proteins. This study measures the effect of >40,000 non-synonymous mutations across the full proteome of coxsackievirus B3, revealing significant variation in mutational tolerance within and between viral proteins, with implications for drug target selection.
Evolutionary #Diversity of #Coxsackievirus A6 Causing Severe #HFMD — #China, 2012–2023, CCDC Weekly, https://weekly.chinacdc.cn/en/article/doi/10.46234/ccdcw2024.086
CVA6, associated with severe HFMD, is evolving and presents a #risk of #outbreak occurrence. Thus, enhanced surveillance of severe HFMD is imperative.
#Virus associated with severe #HFMD found evolving with #risks of #outbreak: #China #CDC, https://www.globaltimes.cn/page/202405/1312928.shtml
#Coxsackievirus A6 (#CVA6), associated with severe hand, foot, and mouth disease (HFMD), is evolving and presents a risk of outbreak occurrence, according to research from the Chinese Center for Disease Control and Prevention (Chinese CDC). An immunologist told the Global Times on Thursday that vaccines would be an effective form of prevention.
#Epidemiology of #HFMD and #genomic #surveillance of #coxsackievirus A10 circulating in #Zhejiang Province, #China during 2017 to 2022, J Clin Virol.: https://doi.org/10.1016/j.jcv.2023.105552 #enterovirus #HEV #vaccines #research #science #medicine
LockharTVMediaDetroit school closes after student dies; officials investigate "unusually high rate" of flu-like cases
Seventeen children fell sick at a Detroit preschool due to hand, foot, and mouth disease. And students at an elementary school are experiencing an unusually high rate of flu-like symptoms. Tragically, one of them — a kindergartener — died.
