Someone on YouTube comments asked me what I thought was in cucurbits (squash/melon family veg) that I react to. I had mentioned previously that Corn Allergy Girl (author of now defunct blog of same name) also reacts to most cucurbits (except cucumber). Here's my response, in case anyone has any input:
" I wish I knew. I'm not even sure if the reaction is due to cross-reactivity with corn allergen or if it is due to mast cell activation syndrome. To complicate things further, Corn Allergy Girl has questioned whether corn allergy is due entirely to reaction with the corn protein zein or if people also react to carbohydrate epitopes (bits of the molecule that makes a pattern that is recognized by the immune system) and I think it might be a possibility. So the reaction to cucurbits might be due to cross-reactivity with a similar carbohydrate found in corn. Humans have antibodies to carbohydrate epitopes (called cross-reactive carbohydrate determinants (CCD)), but they are not supposed to cause allergic reactions and allergy tests are designed to ignore these antibodies. I have wondered what would happen if something went wrong in whatever mechanisms the body uses to ignore CCD antibodies. According to one paper*, 'The role of CCDs and their specific IgE antibodies in the pathophysiology of allergic diseases is controversial. ' "
* http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4757059/
#CornAllergy #MCAS #Allergy #Immunology #Glycobiology