A #SysReview exploring impacts of community-based interventions for adults with #multimorbidity on clinical and patient-reported outcomes (25 studies):
https://bmjpublichealth.bmj.com/content/4/1/e004156
Quick comparison of identified outcomes with the two central #CoreOutcomeSets 👇
Reviewing late phase clinical trials in five medical journals, this #SysReview finds that 98% of trials did not report using core outcome sets, even when relevant #CoreOutcomeSets were available:
https://pubmed.ncbi.nlm.nih.gov/34715310/
See also this recent short piece finding no Patient and Public Involvement #PPI in outcome selection in 44 breast cancer & nephrology trials:
https://link.springer.com/article/10.1186/s13063-022-06980-9
Here, 72% of trials selected non-#PatientCentered outcomes.
COS use in this cohort of trials was low, even when relevant COS were available. Increased use of COS in clinical trials can improve evaluation of intervention effects and evidence synthesis and reduce research waste.
Jan R. Boehnke