Fentanyl overdoses among seniors surge 9,000% — A hidden crisis few saw coming
Overdose deaths from fentanyl mixed with stimulants have skyrocketed among seniors, increasing 9,000% in just eight years. Once thought to affect mainly the young, the opioid epidemic’s fourth wave now engulfs older adults too. Cocaine and methamphetamine are the leading culprits, and experts warn that multi-drug use makes these overdoses especially lethal. Doctors are urged to educate patients and caregivers on prevention and safer pain management.
Norovirus, aka the winter vomiting bug, is on the rise – an infectious disease expert explains the best ways to stay safe
You can get norovirus any time of the year, but it spreads most during the winter.
#Estimates of actual and potential #lives saved in the #USA from the use of #COVID19 #convalescent #plasma
Source: Proceedings of the National Academy of Sciences of the USA, AbstractIn the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we estimated the number of actual inpatient lives saved by…
https://etidioh.wordpress.com/2024/10/09/estimates-of-actual-and-potential-lives-saved-in-the-usa-from-the-use-of-covid19-convalescent-plasma/
#Estimates of actual and potential #lives saved in the #USA from the use of #COVID19 #convalescent #plasma
Source: Proceedings of the National Academy of Sciences of the USA, AbstractIn the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) to treat hospitaliz…
#Estimates of Actual and Potential #Lives Saved in the #USA from the use of #COVID19 #Convalescent #Plasma, MedRxIV, https://www.medrxiv.org/content/10.1101/2024.05.16.24307505v1
CCP deployment was a successful strategy for ameliorating the impact of the COVID-19 pandemic in the USA and this experience has important implications for convalescent plasma used in future infectious disease emergencies.
Estimates of Actual and Potential Lives Saved in the United States from the use of COVID-19 Convalescent Plasma
In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent plasma (CCP) for the treatment of hospitalized patients. Over 500,000 patients were treated with CCP during the first year of the pandemic. In this study, we used CCP weekly use, weekly national mortality data, and CCP mortality reduction data from meta-analyses of randomized controlled trials and real-world data to estimate the number of actual inpatient lives saved by the treatment with CCP in the USA. We also estimate the potential number of lives saved if CCP had been deployed for 100% of hospitalized patients or used in 15% to 75% of outpatients. Depending on the assumptions modeled in stratified analyses, CCP was estimated to have saved between 16,187 and 66,160 lives. The ideal use of CCP might have saved as many as 215,195 lives while preventing 1,136,880 hospitalizations. CCP deployment was a successful strategy for ameliorating the impact of the COVID-19 pandemic in the USA and this experience has important implications for convalescent plasma used in future infectious disease emergencies.
### Competing Interest Statement
The authors have declared no competing interest.
### Funding Statement
This study did not receive any funding
### Author Declarations
I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Yes
I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals.
Yes
I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).
Yes
I have followed all appropriate research reporting guidelines, such as any relevant EQUATOR Network research reporting checklist(s) and other pertinent material, if applicable.
Yes
All data produced in the present study are available upon reasonable request to the authors
#Convalescent #Plasma for
#Covid19–Induced
#ARDS in Mechanically Ventilated Patients, October 26, 2023, N Engl J Med 2023; 389:1590-1600,
DOI: 10.1056/NEJMoa2209502
#SARS_COV_2 #serotherapy #research 
Abandoned hotel (FDGB Erholungsheim Herman Duncker) Germany Oct 2022 (urbex lost places Duitsland)
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Abandoned hotel (FDGB Erholungsheim Herman Duncker) Germany Oct 2022 (urbex lost places Duitsland)
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
High-titer convalescent plasma plus nirmatrelvir/ritonavir treatment for non-resolving COVID-19 in six immunocompromised patients
AbstractObjectives. Immunocompromised patients have an increased risk of severe or prolonged COVID-19. Currently available drugs are registered to treat COVID-1
Abandoned hotel (FDGB Erholungsheim Herman Duncker) Germany Oct 2022 (urbex lost places Duitsland)
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
getmisch
Giuseppe Michieli
Jascha
