Gaspar JekelyPreviously, only one #GPCR with a ligand was known in #cnidaria, the receptor for the #Clytia Maturation-Inducing-Hormone. This receptor was found by Gonzalo Quiroga Artigas and Philipp Bauknecht in our lab, in a collaboration with Evelyn Houliston.
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000614
#cnidaria #neuropeptide #evolution #neuroscience
A G protein–coupled receptor mediates neuropeptide-induced oocyte maturation in the jellyfish Clytia
A study of jellyfish oocytes identifies the receptor for Maturation-Inducing Hormone, the neuropeptide hormone that triggers oocyte maturation and spawning via GαS and cyclic AMP. This receptor defines a superfamily of hormone-receptor systems involved in regulating sexual reproduction across animal species.