Giuseppe MichieliSep 9, 2024

#Treatment #efficacy of #cidofovir & #brincidofovir vs clade II #mpox virus isolates, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224002043?via%3Dihub

Cidofovir & brincidofovir display broad-spectrum #antiviral activity vs MPXV clades I, IIa, and IIb in vitro. Systemic administration of active compound cidofovir prevents MPXV replication in mouse #respiratory tract. Oral treatment with brincidofovir limits viral replication in vivo vs a non-lethal MPXV clade IIb challenge.

Treatment efficacy of cidofovir and brincidofovir against clade II Monkeypox virus isolates

While historically confined to endemic areas, Monkeypox virus (MPXV) infection has increasingly garnered international attention due to sporadic outbr…

Giuseppe MichieliFeb 9, 2023
[Grand Round] Use of #cidofovir in a patient with severe #mpox and uncontrolled #HIV infection https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00044-0/fulltext?rss=yes
Marco RadiDec 17, 2022

NPP-669 is a promising #Cidofovir #prodrug acting as #broad #spectrum #antiviral agent (#BSAA) against multiple DNA #viruses.
An excellent example on how #chemistry / #medicinalchemistry play a key role in the improvement of #drug #bioavalilability and clinical efficacy of #drug candidates.

https://pubs.acs.org/doi/full/10.1021/acs.molpharmaceut.2c00668#