Virtual ChemBioTalksOct 7

We are excited that the 5th Virtual #ChemBioTalks attracted 450 participants from 50 different countries world-wide. Thank you all for making this such an engaging event!

If you want to suggest speakers and keynotes for 2026, please do so by October 31st at ChemBioTalks@gmail.com

#ChemBio #Chemistry #DrugDiscovery

Virtual ChemBioTalksSep 30

We had amazing 5th Virtual #ChemBioTalks. Thank you to all the speakers and organizers for making this possible!

Already mark your calendars for the 6th edition on September 29th, 2026. You are invited to suggest speakers via ChemBioTalks@gmail.com.

#ChemBio #Chemistry #DrugDiscovery

Stephan HackerSep 30
Inspiring talk by Craig @crews at the 5th Virtual #ChemBioTalks. He talked about the power of inducing protein-protein interactions for #DrugDiscovery and the paradigm-shift from occupancy-driven to event-driven pharmacology that this enables. https://www.nature.com/articles/s41573-021-00371-6
PROTAC targeted protein degraders: the past is prologue - Nature Reviews Drug Discovery

Targeted protein degradation with proteolysis-targeting chimeras (PROTACs) has the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. This article summarizes the first two decades of PROTAC discovery and discusses key areas for the future of this therapeutic modality, including establishing the target classes for which it is most suitable and extending its application beyond oncology.

Nature
Stephan HackerSep 30
Inspiring talk by @craigmcrews.bsky.social at the 5th Virtual #ChemBioTalks. He talked about the power of inducing protein-protein interactions for #DrugDiscovery and the paradigm-shift from occupancy-driven to event-driven pharmacology that this enables. www.nature.com/articles/s41...

PROTAC targeted protein degrad...
PROTAC targeted protein degraders: the past is prologue - Nature Reviews Drug Discovery

Targeted protein degradation with proteolysis-targeting chimeras (PROTACs) has the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. This article summarizes the first two decades of PROTAC discovery and discusses key areas for the future of this therapeutic modality, including establishing the target classes for which it is most suitable and extending its application beyond oncology.

Nature
Virtual ChemBioTalksSep 30
Inspiring keynote lecture by Craig @crews at the 5th Virtual #ChemBioTalks. He reported on his group's pioneering work on proximity-inducing molecules for applications in #DrugDiscovery.
https://www.nature.com/articles/s41573-021-00371-6
#Chemistry #ChemBio
Virtual ChemBioTalksSep 30
Very interesting talk by Jenn Prescher at the 5th Virtual #ChemBioTalks. She talked about the tools that her group is developing to track RNA using (multiplexed) bioluminescence. https://www.nature.com/articles/s41467-024-54263-5
Virtual ChemBioTalksSep 30
We had a great Flash Talk session at the 5th Virtual #ChemBioTalks. We heard about #metabolomics to understand bone repair (Jingzhi Fan), fluorogenic triazinium probes (Veronika Šlachtová) and masked acylation reagents for #ChemBio (Shubha Pani).
Virtual ChemBioTalksSep 30
The 5th Virtual #ChemBioTalks continue with an insightful talk by Kelly Chibale. He talked about his group's research into new treatments for #malaria. Great insights into the repurposing of anti #cancer #kinase inhibitors to treat P. falciparum. https://onlinelibrary.wiley.com/doi/10.1002/anie.202425206
Virtual ChemBioTalksSep 30
Insightful talk by Cathleen Zeymer at the 5th Virtual #ChemBioTalks. She talked about the design and evolution of artificial #enzymes for photocatalysis. Interesting insights into both repurposing of existing enzymes and de novo design. https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202517321
Virtual ChemBioTalksSep 30
Exciting talk by Christian Dallago at the 5th Virtual #ChemBioTalks. He talked about the development of #MachineLearning tools to better understand biological systems. Great insights how #BigData from sequencing can be used to predict function. https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(22)00308-5