Aging researchers find new puzzle piece in the game of longevity

The lab of Kris Burkewitz just made a key discovery: How cellular machineries are structured and organized within a cell has implications for healthy aging. “We didn't just add a piece to the puzzle—we found a whole section that hasn't even been touched,” Eric Donahue, first author of the study, said.

Vanderbilt University
“research shows that cells actively reshape the endoplasmic reticulum or ER…Rather than remaining static the ER undergoes controlled remodeling as organisms grow older. The team discovered that this remodeling happens through a process called ER-phagy”
#Science #Cells #CellBio #ER
https://www.sciencedaily.com/releases/2026/02/260203030526.htm
A hidden cellular process may drive aging and disease

As we age, our cells don’t just wear down—they reorganize. Researchers found that cells actively remodel a key structure called the endoplasmic reticulum, reducing protein-producing regions while preserving fat-related ones. This process, driven by ER-phagy, is tied to lifespan and healthy aging. Because these changes happen early, they could help trigger later disease—or offer a chance to stop it.

ScienceDaily

Join our FocalPlane and preLights online event tomorrow.

Felipe and Vibha will present a 'preLight' on their chosen preprints followed by research talks from Carmen Rodilla-Ramírez and Eva Mejia-Ramirez, the authors of the preprints.

Register now:

https://focalplane.biologists.com/2025/08/20/focalplane-features-meets-prelights/

#FocalPlaneFeatures #CellBio #PrePrints #Microscopy #Research #Biology

July in preprints, the CellBio edition, is out now on the preLights website.

Thanks to Girish Kale, Matthew Davies, Barbora Knotkova and Sristilekha Nath for their contributions.

Have a look:

https://prelights.biologists.com/prelists/july-in-preprints-the-cellbio-edition/

#PrePrints #Academia #Publishing #Science #Biology #Research #CellBio #PreLights

Scientists have found a new way to recreate inner ear hair cells in the lab to study hearing loss.
https://elifesciences.org/reviewed-preprints/106550?utm_source=mastodon&utm_medium=social&utm_campaign=organic_pr
#DevBio #CellBio

May in #preprints – the #CellBio edition!

Curated by #preLighters from across the field. Barbora Knotkova, Matthew Davies, Girish Kale, Chee Kiang Ewe, Felipe Del Valle Batalla & Sristilekha Nath

New discoveries and bold hypotheses you shouldn’t miss.
#preList ⬇️
https://prelights.biologists.com/prelists/may-in-preprints-the-cellbio-edition/

May in preprints – the CellBio edition - preLights

preLights

🧬 Sticky situation in the nucleolus?

A new study shows that the ‘Treacle’ protein forms liquid-like condensates that organise nucleolar structure and keep ribosome production flowing. #Genetics #CellBio
https://elifesciences.org/articles/96722?utm_source=mastodon&utm_medium=social&utm_campaign=organic

Issue 7 is complete

Explore our ToC: https://journals.biologists.com/jcs/issue/138/7
Our cover image shows the musculature (turquoise, phalloidin) & tendon cells (red, tendon cell-driven F-tractin–RFP) of a formin 3 mutant Drosophila larva (Pissarek et al.)
https://journals.biologists.com/jcs/article/138/7/jcs263543/367667/Formin-3-stabilizes-the-cytoskeleton-of-Drosophila

Also in Issue 7:
- Research Highlights on ATG9A INVs, airway epithelia & Formin 3
- JCS–David Stephens Prize
- Emmanuel Derivery Interview
- Regulation of cell migration by ECM mechanics
- Data exploration in quantitative #cellbio

It’s about time to share the March #CellBio preprint picks! #preList

8 preLighters teamed up to curate a preprint reading lists across different categories in cell biology, including cancer biology, cell migration, cell signalling and mechanosensing & more

Check out the preList! ⬇️ 👀
https://prelights.biologists.com/prelists/march-in-preprints-the-cellbio-edition/

#SciComm #biology #community #ReadingList #bioRxiv #preprints

March in preprints – the CellBio edition - preLights

preLights

February in #preprints – the #CellBio edition!

This month the list was curated by Barbora Knotkova, Matthew Davies, Sristilekha Nath, Girish Kale, Prasanna Padmanaban, Vibha SINGH & Felipe Del Valle Batalla 🙌 #community #ECRs

Explore their favourite #CellBio #preprints!

#preList⬇️
https://prelights.biologists.com/prelists/february-in-preprints-the-cellbio-edition/

#SciComm #biology #community #ReadingList #bioRxiv

February in preprints – the CellBio edition - preLights

preLights