A John Camm, Thomas F Lüscher, Patrick Serruys The ESC Textbook of Cardiovascular Medicine (2019) by A. John Camm and Thomas F. Lüscher
Author: A. John Camm and Thomas F. Lüscher
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'Multimorbidity Patterns in Patients with Pulmonary Arterial Hypertension Identified Through Hospital Discharge Records: A Network-Based Analysis' - an article in Cardiovascular Innovations and Applications on #ScienceOpen:
🔗 https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2025.0008
🖇️ #CardiovascularMedicine #CardiologyResearch #Multimorbidity #NetworkMedicine
Multimorbidity Patterns in Patients with Pulmonary Arterial Hypertension Identified Through Hospital Discharge Records: A Network-Based Analysis
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<h5 class="section-title" id="d7816681e173">Background:</h5>
<p dir="auto" id="d7816681e175">Considerable variability exists in the clinical presentations of pulmonary arterial
hypertension (PAH). Greater understanding of the comorbidities observed in Chinese
patients with PAH is urgently needed.
</p>
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<h5 class="section-title" id="d7816681e178">Methods:</h5>
<p dir="auto" id="d7816681e180">This 10-year retrospective analysis was based on clinical data from hospital discharge
records for individuals diagnosed with PAH (n = 2584). We used propensity score matching
to match patients with PAH to individuals without a PAH diagnosis in a ratio of 1:1,
by age, sex, discharge time, and department, over the same period. We constructed
multimorbidity networks based on sex and age, and used the cosine index to measure
the co-occurrence of chronic diseases.
</p>
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<h5 class="section-title" id="d7816681e183">Results:</h5>
<p dir="auto" id="d7816681e185">The mean numbers of comorbidities were 4.7 and 3.8 for patients with PAH and controls,
respectively. The main central and hub disorders were renal osteodystrophy, cardiovascular
illnesses, background retinopathy, diabetes mellitus, systemic lupus erythematosus,
epilepsy, and autoimmune hemolytic anemia. The average neighbor degree and closeness
were significantly smaller in the multimorbidity networks of patients with PAH than
control participants (Kolmogorov–Smirnov test, all P < 0.05).
</p>
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<h5 class="section-title" id="d7816681e188">Conclusion:</h5>
<p dir="auto" id="d7816681e190">Our findings may aid in preventing comorbidities among patients with PAH and deepening
understanding of the underlying physiopathological mechanisms.
</p>
</div>
'Comparative Analysis of Surgical Outcomes in Cardiac Myxoma Resection: Sternotomy Versus Right Mini-Thoracotomy' - a new #OpenAccess article in 'Cardiovascular Innovations and Applications' on #ScienceOpen:
🔗 https://www.scienceopen.com/hosted-document?doi=10.15212/CVIA.2025.0015
#Research #Medicine #CardiovascularMedicine #Surgery
Comparative Analysis of Surgical Outcomes in Cardiac Myxoma Resection: Sternotomy Versus Right Mini-Thoracotomy
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<h5 class="section-title" id="d7623327e172">Objective:</h5>
<p dir="auto" id="d7623327e174">Despite increasing use of minimally invasive techniques, limited literature has described
minithoracotomy for removal of left atrial masses, such as myxomas. This study was
aimed at addressing this gap by analyzing more than a decade of experience at our
center.
</p>
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<h5 class="section-title" id="d7623327e177">Methods:</h5>
<p dir="auto" id="d7623327e179">Between January 2010 and May 2024, 116 patients underwent either right minithoracotomy
or median sternotomy for left atrial myxoma resection. This retrospective study included
96 patients and excluded 20 patients receiving additional procedures. No prior sample
size calculation was performed.
</p>
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<h5 class="section-title" id="d7623327e182">Results:</h5>
<p dir="auto" id="d7623327e184">The patients were divided into two groups: 36 (37.5%) who underwent right anterolateral
minithoracotomy and 60 (62.5%) who underwent median sternotomy. Both groups had similar
clinical characteristics (age P = 0.254, sex P = 0.274, BMI P = 0.128, and EuroSCORE
II P = 0.470), tumor size (P = 0.596), and location (P = 0.954). No significant differences
were found in intensive care unit or hospital length of stay, or major complications.
The extracorporeal circulation time was shorter with sternotomy, despite similar cross-clamp
times between techniques (P = 0.085). After inverse probability weighting, no significant
differences were found in in-hospital mortality. Atrial fibrillation incidence was
lower with minithoracotomy (P < 0.001).
</p>
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<h5 class="section-title" id="d7623327e187">Conclusions:</h5>
<p dir="auto" id="d7623327e189">Minimally invasive resection of left atrial myxomas is as safe and effective as median
sternotomy. Larger studies are required to validate these results.
</p>
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DOACs Not Linked to Increased Intracranial Hemorrhage Risk
A new meta-analysis found direct oral anticoagulants were less likely than antiplatelet therapy to cause intracranial hemorrhage and reinforced adherence to current guidelines for managing atrial fibrillation.
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