Dose makes the difference! #Candidaalbicans uses the toxin #candidalysin not only to cause infections but also to quietly colonize the mouth – too little fails, too much triggers immune defense.
#NatureMicrobiology
@LeibnizHKI

🗞️ Press release: https://shorturl.at/AzMAg
🧪Original paper: https://doi.org/10.1038/s41564-025-02122-4

picture credits: Erik Böhm, Leibniz-HKI

La levadura Candida albicans aumenta la virulencia de Salmonella en el intestino

Un factor más para tener en cuenta.

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La levadura Candida albicans aumenta la virulencia de Salmonella en el intestino

@iabot ¿Cómo puede la interacción entre *Candida albicans* y *Salmonella Typhimurium* afectar la respuesta inmune y qué implicaciones tiene esto para el tratamiento de infecciones intestinales?

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🦘🌤️ The corona pandemic led to the design of new synthetic polymers against fungal infections, thanks to a unique 🇦🇺🤝🇩🇪 collaboration, and to a study now in #NatureCommunications. Big congrats to the entire reserach team!

👉https://www.nature.com/articles/s41467-024-50491-x#citeas

@unijena
@bmbf_bund @dfg_public

#SyntheticPolymers #AntiFungals #FungalBiotechnology #FungalInfections #Candida #CandidaAlbicans #UNSW #Australia #Germany #ResearchCollab #ResearchCollaboration #LeibnizHKI

Health, nutrition and exercise – all these aspects apply to today’s #Women’s Health Day! 🧘🏾‍♀️🌸

@LeibnizHKI has been studying #CandidaAlbicans, a fungus which can cause genital infections in millions of women worldwide. New results raise hope that with the help of nanobodies, the activity of the fungus’ toxin Candidalysin can be blocked. In the laboratory, the nanobodies very effectively reduced toxin-induced tissue damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10936171/

#WomensHealth
#WomensHealthDay

New study published in the journal "Nature" finds Candida albicans toxin Candidalysin crucial for gut colonization.
Researchers from @LeibnizHKI and Brown University reveal its antibacterial effect, enhancing the fungus’ competitive edge against gut bacteria.
👇
https://leibniz-hki.de/en/press-release/toxin-von-candida-albicans-spielt-besondere-rolle-bei-der-besiedelung-des-verdauungstrakts-2.html

#Microbiome #BalanceOfTheMicroverse #ResearchCollaboration #CandidaAlbicans

🏆 Winner 4/4 of the medac research award: Certain T helper cells transform intracellular proteins to build #cytokines releasing them through holes in cell membranes to attract cells destroying harmful #CandidaAlbicans.🧫💡 #MedacResearch #ResearchAward

👉 Full publication here: https://doi.org/10.1038/s41590-022-01386-w!

@unijena
@LeibnizHKI

Experts sound the alarm over #drugresistant #fungal infection detected in US

Story by Matthew Dooley, December 4, 2023

"Experts are sounding the alarm about a highly contagious #fungaldisease that's becoming resistant to common drugs. They warn this could make illnesses like #thrush much harder to treat.

"Medical professionals have warned that the world is not prepared for the growing threat of fungal infections.

"These can range from common conditions like #ringworm and thrush to life-threatening bloodstream infections caused by #CandidaAlbicans and #CandidaAuris.

"David Denning, a professor at the University of Manchester, previously spoke to The Mirror about a drug-resistant form of #ringworm. He explained how this fungus can easily spread in schools and homes.

"He said: 'Skin fungal infections are transmitted from one person to another in schools, homes and with intimate contact. This new #TerbinafineResistant fungus is a new species called #TrichophytonIndotineae and [was] first identified in India.

"Experts believe the rise in resistant fungi is due to overuse of over-the-counter #antifungal creams, misuse of #TopicalSteroid creams, incorrect prescription of antifungal drugs, as well as patients not sticking to prescribed courses of antifungal medication."

Full article: https://www.msn.com/en-us/health/medical/experts-sound-the-alarm-over-drug-resistant-fungal-infection-detected-in-us/ar-AA1kYAGN?rc=1&ocid=winp1taskbar&cvid=385d94e96b274f72942909e01780ddbc&ei=5

#Fungal #DrugResistance

Visualizing #fungal infections deep in living host tissue reveals proline #metabolism facilitates virulence https://phys.org/news/2023-11-visualizing-fungal-infections-deep-host.html

Proline catabolism is a key factor facilitating #CandidaAlbicans pathogenicity https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011677

"the opportunistic human fungal pathogen #Candida albicans requires the ability to metabolize #proline, an amino acid obtained from the host, to mount virulent infections."

#fungi #pathogens #AminoAcids #microbes