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`The resulting ‘jGCaMP8’ sensors, based on the calcium-binding protein calmodulin and a fragment of endothelial nitric oxide synthase, have ultra-fast kinetics (half-rise times of 2 ms) and the highest sensitivity for neural activity reported for a protein-based calcium sensor. jGCaMP8 sensors will allow tracking of large populations of neurons on timescales relevant to neural computation.`

https://www.nature.com/articles/s41586-023-05828-9

#proteinEngineering #calciumIons #kinetics #neuroscience #neuroimaging #sensing

Fast and sensitive GCaMP calcium indicators for imaging neural populations - Nature

Using large-scale screening and structure-guided mutagenesis, fast and sensitive GCaMP sensors are developed and optimized with improved kinetics without compromising sensitivity or brightness.

Nature