Akash JosephMay 30, 2025

https://rackenzik.com/cytochrome-p450-the-key-to-drug-metabolism-and-mental-health/

#CytochromeP450 #CYP450 #Pharmacology #DrugMetabolism #EnzymeScience #Pharmacogenomics #PrecisionMedicine #DrugInteraction #Biochemistry #Toxicology #Metabolism #PersonalizedMedicine #PharmaceuticalScience

Cytochrome P450: The Key to Drug Metabolism and Mental Health - Rackenzik

Cytochrome P450 regulates drug metabolism, shaping psychiatric treatment with precision medicine and genetic insights for better care.

Rackenzik
freewheelingNov 8, 2022

Harnessing #Renewable carbon from lignin? We've got you! 🌲 β™₯️ πŸ™Œ

In collaboration with Dr Stephen Bell, awesome #Science PhD candidate Alix Harlington has published the first description of a #Cyp450 syringol O-demethylase we've called SyoA. AND he's achieved hydrogen peroxide driven turnovers making this a simple, clean and cheap reaction... A thread:

https://pubs.rsc.org/en/Content/ArticleLanding/2022/CC/D2CC04698A

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synt