Ron Beavis ❌Dec 16, 2023
α⧸ω ST phosphorylation diagram for human C-X-C motif chemokine receptor 4 (#CXCR4:p). This protein has a blank N-terminal, extracellular IDR, 7 transmembrane helical domains connected by unstructured loops and a rather frantically modified, low complexity intracellular phospho-IDR at the C-terminus. #proteomics
Ron Beavis ❌Dec 16, 2023

Best known for its antics when paired with T cells, this protein is also present but near the LOD on many in the leukocyte family.

#CXCR4:p (C-X-C motif chemokine receptor 4): Human Protein Atlas mRNA tissue distribution and GPMDB protein tissue & cell type tabbulations. #proteomics

CellBioNewsNov 24, 2023

Certain #plant #proteins resemble #human #signaling proteins of the #immune system and can bind to their receptors.

#cytokine #MDL #MIF #CXCR2 #CXCR4

https://phys.org/news/2023-11-proteins-resemble-human-immune-receptors.html

Certain plant proteins resemble human signaling proteins of the immune system and can bind to their receptors

The human immune system is based on cells that communicate with each other via signaling molecules known as cytokines and chemokines. One of these signaling molecules is the protein MIF (macrophage migration inhibitory factor). It plays an important role in the regulation of various immune reactions by binding to suitable receptors of various cell types in a ternary complex, thereby activating certain signaling pathways in these cells.

Phys.org