Directed molecular evolution of muscarinic receptors
π Evolved GPCRs activated by CNO, not acetylcholine
π§ͺ CNO activates M3 with 20-30 nM potency
π¬ hM4D receptor induces neuronal silencing for mtd
#GCPR #CNO #DREADD #hM3D #hM4D #molecularEvolution
https://dev.https://tnyp.me/CcS0q4hQ/m

