#Marijuana Extract Can Kill #Melanoma Cells, New Study Reveals Possible Treatment For #SkinCancer
Story by Nina Zdinjak
February 8, 2024
"A new study indicates #cannabis has the potential to treat melanoma, a skin cancer beginning in the melanocyte cells, which make the pigment that gives skin its color.
"Melanoma typically results from over-exposure to the sun. While skin cancer is one of the most common cancers in the United States, melanoma accounts for only about 1%, yet causes a large majority of skin cancer deaths, according to the American Cancer Society.
"New research published in a peer-reviewed Cell Journal conducted by scientists from Charles Darwin University (CDU) and RMIT University offers hope for the creation of a natural treatment for melanoma.
"The study, part of a Ph.D. project by RMIT's Dr. Ava Bachari, showed that a specific cannabis extract (#PHEX66) from the #CannabisSativa plant binds to receptor sites on particular melanoma cells, controlling its growth at two key phases and increasing the amount of damage to these cells.
"Dr. Nazim Nassar, the study co-author and CDU pharmaceutical lecturer said this damage practically tricks cells into killing itself, writes Mirage News. This inhibitory effect arises from interactions with #CB1 and #CB2 receptors, the paper reads.
"'The damage to the melanoma cell prevents it from dividing into new cells, and instead begins a programmed cell death, also known as #apoptosis,' Dr. Nassar said. 'This is a growing area of important research because we need to understand cannabis extracts as much as possible, especially their potential to function as anticancer agents. If we know how they react to cancer cells, particularly in the cause of cell death, we can refine treatment techniques to be more specific, responsive and effective'.
"According to Nassar, who specializes in cancer cell biology, pharmacology and drug delivery systems, the next step should be to create a targeted delivery system for the melanoma cells in preparation for pre-clinical trials.
"'Clinical uses of cannabis extracts include treatment for anxiety, cancer-related symptoms, epilepsy, and chronic pain. Intensive research into its potential for killing melanoma cells is only the start as we investigate how this knowledge can be applied to treating different types of cancers,' Nassar said.
"Professor Nitin Mantir, lead author and RMIT biotechnologist, said there needs to be a thorough follow-up to assess the long-term efficiency and safety of the PHEC-66 extract.
"'The subsequent stage involves animal studies or pre-clinical trials to validate and further explore the efficacy of cannabinoid PHEC-66 in treating melanoma and other cancers,' Mantri said.
"Both authors stressed the need for support and sponsorship to eventually qualify PHEC-66 as a registered medicine."
Link to related article:
https://www.cdu.edu.au/news/new-study-reveals-kill-order-melanoma-cells-cannabis-extract
#Cannabinoids as novel #AntiInflammatory drugs
by Prakash Nagarkatti, et al.
October, 2009
Abstract:
"Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (#THC) as the major psychoactive principle in marijuana, as well as the identification of #cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system. The fact that both CB1 and CB2 receptors have been found on #immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Recent studies demonstrated that administration of THC into mice triggered marked apoptosis in T cells and dendritic cells, resulting in immunosuppression. In addition, several studies showed that cannabinoids downregulate #cytokine and chemokine production and, in some models, upregulate T-regulatory cells (Tregs) as a mechanism to suppress #inflammatory responses. The #endocannabinoid system is also involved in #immunoregulation. For example, administration of endocannabinoids or use of inhibitors of enzymes that break down the endocannabinoids, led to immunosuppression and recovery from immune-mediated injury to organs such as the liver. Manipulation of endocannabinoids and/or use of exogenous cannabinoids in vivo can constitute a potent treatment modality against inflammatory disorders. This review will focus on the potential use of cannabinoids as a new class of anti-inflammatory agents against a number of inflammatory and autoimmune diseases that are primarily triggered by activated T cells or other cellular immune components."
Executive summary
- Cannabinoids, the active components of #CannabisSativa, and endogenous cannabinoids mediate their effects through activation of specific cannabinoid receptors known as cannabinoid receptor 1 and 2 (CB1 and CB2).
- The cannabinoid system has been shown both in vivo and in vitro to be involved in regulating the immune system through its immunomodulatory properties.
- Cannabinoids suppress inflammatory response and subsequently attenuate disease symptoms. This property of cannabinoids is mediated through multiple pathways such as induction of apoptosis in activated immune cells, suppression of cytokines and chemokines at inflammatory sites and upregulation of FoxP3+ regulatory T cells.
- Cannabinoids have been tested in several experimental models of autoimmune disorders such as #MultipleSclerosis, #RheumatoidArthritis, #colitis and #hepatitis and have been shown to protect the host from the pathogenesis through induction of multiple anti-inflammatory pathways.
- Cannabinoids may also be beneficial in certain types of #cancers that are triggered by #ChronicInflammation In such instances, cannabinoids can either directly inhibit tumor growth or suppress inflammation and tumor angiogenesis.
Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ[9] -tetrahydrocannabinol (THC) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors ...
Enjoying some tasty #Cannabis in vaped form tonight. It's a live resin cart of #Batzinga from #SundayExtracts, grown right here in #Oklahoma It has some minty and piney notes, almost like an #IPA of a smoke. The effects are cerebral. Some munchies but not as bad as some others I've had lately. This one is strong and flavorful.
#StrainReview #MedicalMarijuana #Marijuana #CannabisSativa #Herb #OKMJ #OklahomaMarijuana
Bei Drogen wird zunächst an Kokain, Ecstasy oder #Cannabis gedacht
Daneben gibt es aber zahlreiche halluzinogen wirkende Naturdrogen, die zum Teil relativ leicht zugänglich sind. Bereits in der Steinzeit genoss man so manche sinnverwirrende Pflänzchen und Schwammerl, bis heute sorgen sie für Rausch und Stoff für die #Forschung.
Die Welt der #Drogen: Welche Pflanzen und Pilze uns berauschen können
#Cannabissativa #Schlafmohn #PeyoteKaktus #Fliegenpilz #Tollkirsche
https://www.derstandard.de/story/2000135815445/narrische-flora-welche-pflanzen-und-pilze-uns-berauschen-koennen
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