Kemal21h ago

From Lab Bench to Browser: A Hybrid Digital Twin for CHO Cell Culture

I rebuilt two published CHO cell-culture papers — a hybrid ODE + machine-learning growth model, and a genome-scale metabolic reduction pipeline — as an interactive digital twin that runs in the browser. Here's how it works, what's under the hood, and an honest take on what it's good for. No hosted version yet; the code is on GitHub and a live instance is coming soon.

https://kemal.yaylali.uk/cho-cell-culture-digital-twin-browser/

KemalMay 22

The Ovalbumin Patent Fight and What It Tells Us About Where Precision Fermentation Is Going

The Every Company and Onego Bio are now fighting over recombinant ovalbumin in courts on two continents. The way this case resolves will shape how broadly IP rights can be enforced in precision fermentation, and what that means for the rest of us building this industry.

https://kemal.yaylali.uk/the-ovalbumin-patent-fight-and-what-it-tells-us-about-where-precision-fermentation-is-going/

KemalMay 15

Living with a Mechanical Mitral Valve and Warfarin: The Diet, the Biochemistry, and What Nobody Tells You Until It’s Too Late

What I wish someone had handed me on discharge day: the biochemistry of warfarin and vitamin K, the food atlas, the drug and herbal interactions, travel, and the daily operating procedure of life on warfarin with a mechanical mitral valve. Written engineer-to-engineer.

https://kemal.yaylali.uk/warfarin-vitamin-k-mechanical-mitral-valve/

KemalFeb 19

Running a 5-Litre Lysine Fermentation From Scratch. Everything Nobody Tells You

Corynebacterium glutamicum under a scanning electron microscope. Urska Repnik, CAU Kiel, CC BY 4.0 If you've ever read a paper on lysine production with Corynebacterium glutamicum and thought "right, but what do I actually do on Monday morning when I'm standing in front of the bioreactor" — this post is for you. I'm going to walk through the entire process of setting up and running a 5L bench-scale fed-batch lysine fermentation. Not the textbook version. The real version. The one where […]

https://kemal.yaylali.uk/running-a-5-litre-lysine-fermentation-from-scratch-everything-nobody-tells-you/

KemalJan 24

How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures

A bioprocess engineer's journey into machine learning and why the pharmaceutical industry desperately needs this bridge When I tell people I work in bioprocess engineering, I usually get blank stares. When I explain that I help manufacture proteins in giant tanks for therapeutic use, the response is often: "Oh, like brewing beer?" Not quite. But close enough. What I don't usually mention is that I've been teaching myself machine learning on nights and weekends. Not because it's trendy, but […]

https://kemal.yaylali.uk/from-bioreactors-to-ai-how-i-built-a-machine-learning-tool-to-predict-drug-manufacturing-failures/

How I Built a Machine Learning Tool to Predict Drug Manufacturing Failures – Kemal's

PsychoticSheepOct 21, 2025
Today was the day: I presented my bachelor’s thesis!
Just a few exams left – and then my studies are officially done!

Background: FORBIX is an FWF START Prize project that investigates how the acetogen Acetobacterium woodii can be engineered and optimized to convert sustainably produced formate into valuable chemicals such as alcohols and organic acids.
Link: https://www.tuwien.at/en/tch/icebe/e166-04/e166-04-1-research-group-for-bioprocess-technology/group-industrial-biotechnology/research-and-projects/forbix-formiat-basierte-acetogene-bioproduktion-von-treibstoffen-und-chemikalien

#Bachelorarbeit #BScThesis #PresentationDay #Biotechnology #BioprocessEngineering #MetabolicEngineering #Microbiology #Acetogens #FormateToX #RenewableCarbon #SustainableBiotech #FWF #ResearchLife #ScienceCommunication #FutureScientist #AcademicJourney #ProudMoment #AlmostGraduated #ScienceIsCool
Technische Universität MünchenDec 6, 2023

Watch the latest episode of "NewIn“ with Michael Zavrel, Professor of #BioprocessEngineering at our Straubing campus, where he talks about his goal to transform a #fossilbased economy into a #bioeconomy: http://go.tum.de/030536

#sustainability #biofuels

📷A.Eckert
▶https://youtu.be/g4RE6l9uXTg
🎥@prolehre

Hands-on expertise for the bioeconomy

Michael Zavrel has worked on the development of industrial bioprocesses that turn waste into high-quality products. Now the Professor of Bioprocess Engineering

Max Planck Institute MagdeburgMar 27, 2023
📢 #JobAlert! Interested biocatalytic reaction networks for the production of oligosaccharides? Then apply now for the #postdoc position in #BioprocessEngineering of Biocatalytic Cascades in our #SyntheticBiotechnology Team! Deadline: 10 April 2023
https://www.mpi-magdeburg.mpg.de/4389037/job_full_offer_20028958?c=1141784
Postdoc position (m/f/d) | Bioprocess Engineering of Biocatalytic Cascades

Postdoc position (m/f/d) | Bioprocess Engineering of Biocatalytic Cascades. Biocatalytic reaction networks for the production of oligosaccharides are of steadily increasing significance in the biopharmaceutical and food industry.

Max Planck Institute MagdeburgMar 27, 2023
📢 #JobAlert! Biokatalytische Reaktionsnetzwerke zur Herstellung von Oligosacchariden klingt spannend? Dann bis 10. 04.2023 für die #Postdoc-Stelle in "#BioprocessEngineering of Biocatalytic Cascades" in unserem #SyntheticBiotechnology Team bewerben!
https://www.mpi-magdeburg.mpg.de/4389037/job_full_offer_20028958?c=1141784
Postdoc position (m/f/d) | Bioprocess Engineering of Biocatalytic Cascades

Postdoc position (m/f/d) | Bioprocess Engineering of Biocatalytic Cascades. Biocatalytic reaction networks for the production of oligosaccharides are of steadily increasing significance in the biopharmaceutical and food industry.