Mastodawn

The p53 protein, widely known as the "guardian of the genome," is a crucial tumor suppressor that is mutated in approximately half of all cancer cases; researchers have engineered miniature antibodies called DARPins to stabilize these mutated proteins and restore their protective function.
#Oncology #MolecularBiology #BiophysicalChemistry #Pharmaceutical #sflorg
https://www.sflorg.com/2026/04/ongy04292601.html

Mini-Antibodies Reactivate the Guardian of the Genome

With more than 2,000 distinct p53 mutations identified across different cancers, developing customized treatments for each variant is highly impractic

Scientific Frontline Apr 16

Cell membranes serve as more than just structural scaffolds and environmental barriers; they actively influence the behavior and signaling processes of the protein receptors embedded within them. Specifically, the lipid composition of a membrane can directly alter the functional state of critical cellular components like the epidermal growth factor receptor (EGFR).
#Biochemistry #CellBiology #BiophysicalChemistry #Oncology #sflorg
https://www.sflorg.com/2026/04/bchm04162601.html

MIT study reveals a new role for cell membranes

Long thought to be mainly a structural support, the cell membrane also influences how cells respond to signals and may contribute to the growth of can

David Grayless Mar 20

The Journal of Physical Chemistry B is a #peerreviewed #scientificJournal that covers research on several fields of material chemistry (macromolecules, soft matter, and #surfactants) as well as #statisticalMechanics, #thermodynamics, and #biophysicalChemistry. It has been published weekly since 1997 by the #AmericanChemicalSociety. According to the #JournalCitationReports, the journal had an #impactFactor of 3.5 for 2023. Due to the growing amount of research in the fields it covers.

Academic Europe Mar 17, 2025

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Academic Europe Feb 21, 2025

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