Before you continue to YouTube

Magnesium Glycinate: The Unsung Hero of Sleep, Muscle Recovery, and More

The gentle hum of crickets outside her window was usually a lullaby for Maya, but tonight, sleep evaded her. Her legs twitched, a familiar, restless ache that h

Metallic Minerals vs. Plant Minerals: Key Nutritional Differences

Unlock the health benefits of plant minerals over metallic minerals. Learn how plant minerals, with superior absorption and diverse nutrients, support optimal well-being and vitality.

Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes

Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects. No pharmacokinetic and bioavailability data on geraniol are currently available. We therefore performed a systematic study to identify the permeation properties of geraniol across intestinal cells, and its pharmacokinetics and bioavailability after intravenous and oral administration to rats. In addition, we systematically investigated the potential hepatotoxic effects of high doses of geraniol on hepatic phase I, phase II and antioxidant enzymatic activities and undertook a hematochemical analysis on mice. Permeation studies performed via HPLC evidenced geraniol permeability coefficients across an in vitro model of the human intestinal wall for apical to basolateral and basolateral to apical transport of 13.10 ± 2.3 × 10-3 and 2.1 ± 0.1⋅× 10-3 cm/min, respectively. After intravenous administration of geraniol to rats (50 mg/kg), its concentration in whole blood (detected via HPLC) decreased following an apparent pseudo-first order kinetics with a half-life of 12.5 ± 1.5 min. The absolute bioavailability values of oral formulations (50 mg/kg) of emulsified geraniol or fiber-adsorbed geraniol were 92 and 16%, respectively. Following emulsified oral administration, geraniol amounts in the cerebrospinal fluid of rats ranged between 0.72 ± 0.08 μg/mL and 2.6 ± 0.2 μg/mL within 60 min. Mice treated with 120 mg/kg of geraniol for 4 weeks showed increased anti-oxidati...

Strategies to increase the bioaccessibility and bioavailability of iron and zinc from cereal products | Proceedings of the Nutrition Society | Cambridge Core

Strategies to increase the bioaccessibility and bioavailability of iron and zinc from cereal products