HOBIT is a fully integrated, wireless implantable device that houses engineered, drug-producing cells and sustains them by actively generating local oxygen. It solves the critical challenge of keeping dense clusters of therapeutic cells alive in poorly oxygenated areas of the body, such as under the skin.
#Bioengineering #Biomedical #MaterialsScience #Engineering #Bioelectronics #sflorg
https://www.sflorg.com/2026/03/beng03272601.html
Solving the oxygen problem in cell-based drug delivery

Localized oxygen generation supports dense clusters of drug-producing cells in a compact implant

High-pressure freezing is a novel #cryopreservation technique that utilizes extreme pressure and rapid cooling to instantaneously freeze biological samples into a noncrystalline solid state via vitrification.
#Cryobiology #Bioengineering #CellBiology #RegenerativeMedicine #sflorg
https://www.sflorg.com/2026/03/beng03252601.html
Successful use of high-pressure freezing for cell cryopreservation

A high-pressure method of instantaneously freezing cells proves to be effective in the first empirical validation of its kind.

`In this study, Thalassiosira weissflogii was transformed into biohybrid microrobots (Mag-Diatoms) while retaining its natural chlorophyll, thereby enabling Mag-Diatom-mediated photodynamic therapy (PDT) without additional drug modification.`

http://dx.doi.org/10.1631/bdm.2500276

#diatom #microrobot #bioengineering

`Here, we demonstrate artificial neurons that not only closely emulate biological neurons in functions but also match their parameters in key aspects such as signal amplitude, spiking energy, temporal features, and frequency response. Moreover, these artificial neurons can be modulated by extracellular chemical species in a manner consistent with neuromodulation in biological neurons.`

http://dx.doi.org/10.1038/s41467-025-63640-7

#bioengineering #neuroscience #neuron #bacteria #geobacter

When Your Apple Watch Becomes an Office Taskmaster

A proliferation of data from wearable technology is telling people how to optimize their job performance. Is that a good thing?

The New York Times
A novel stem cell therapy that integrates biodegradable #nanogel microfibers into three-dimensional cell clusters (#spheroids ) to enhance stem cell survival, oxygen diffusion, and functional regeneration of injured swallowing muscles.
#Bioengineering #MaterialScience #CellBiology #sflorg
https://www.sflorg.com/2026/03/beng03142601.html
Giving stem cells room to breathe

Stem cell therapy is considered a promising strategy for muscle repair

`Herein, we modified the rheological properties of the bioactive hydrogel by incorporating a thixotropic laponite nanoclay (LPN) and demonstrated that an optimized ratio of collagen methacrylate (ColMA) to LPN forms a self-healing suspension bath, which is enhanced by hydrogen bonding interactions and is capable of in situ crosslinking. This printing strategy was generalized as the embedded 3D printing in cell-dense suspension (EPICS).`

http://dx.doi.org/10.1088/2631-7990/ae3347

#bioprinting #bioengineering

Radware Bot Manager Captcha

Super-resolution functional #photoacoustic #microscopy enables the imaging of blood flow and oxygenation at single-cell resolution within the mouse brain without requiring #cellular contrast labels.
#Bioengineering #Biomedical #Neuroscience #sflorg
https://www.sflorg.com/2026/03/beng03102601.html
Tracking single red blood cells as they move through the brain

With a new tool developed at WashU, functional photoacoustic microscopy reaches super-resolution

Researchers at Rice University and Baylor College of Medicine utilized a non-editing #CRISPR technique to safely increase #mitochondrial production in heart cells, improving cellular energy levels without causing cellular burnout or malfunction.
#MolecularBiology #Bioengineering #Genetics #sflorg
https://www.sflorg.com/2026/03/mbio03092601.html
CRISPR-based technique unlocks healing power of mitochondria for heart failure therapy

After a heart attack, the heart struggles to recoup and maintain energy. One third of patients develop heart failure as a result