ππͺ° Separated by evolution, connected by the same developmental code.
π Digital cousins: Simultaneous optimization of one model for BMP signaling in distant relatives reveals essential core. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.08.021
π CSBJ: https://www.csbj.org/
#BMPsignaling #DevelopmentalBiology #SystemsBiology #ComputationalBiology #EvolutionaryBiology #BiophysicalModeling #Bioinformatics #SyntheticBiology #QuantitativeBiology
Cell-cell signaling needs to be precisely controlled for proper development & homeostasis. @melisa_degroot &co @CornellMBG show that the secreted Ca-binding protein SMOC regulates
#BMPsignaling in
#Celegans by binding to both BMP & glypican
#PLOSBiology https://plos.io/47BOphw
SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans
Cell-cell signaling needs to be precisely controlled to ensure proper development and homeostasis. This study shows that the conserved secreted modular calcium binding protein, SMOC, regulates bone morphogenetic protein (BMP) signaling in the nematode C. elegans by binding to both BMP and glypican.
CSBJ
PLOS Biology