Mastodawn

Giuseppe Michieli Oct 15, 2024

#Clinical #profile analysis of #SARS-CoV-2 #community #infections during periods with #omicron #BA2, #BA4/5, and #XBB dominance in #HK: a prospective cohort study

Source: Lancet Infectious Diseases, SummaryBackgroundExisting studies on SARS-CoV-2 infection have mainly focused on severe clinical outcomes; understanding of the clinical severity profile of general community infections is poor. We aimed to assess and compare the clinical profiles of infections with…

https://etidioh.wordpress.com/2024/10/15/clinical-profile-analysis-of-sars-cov-2-community-infections-during-periods-with-omicron-ba2-ba4-5-and-xbb-dominance-in-hk-a-prospective-cohort-study/

#Clinical #profile analysis of #SARS-CoV-2 #community #infections during periods with #omicron #BA2, #BA4/5, and #XBB dominance in #HK: a prospective cohort study

ETIDIoH

Giuseppe Michieli Jul 2, 2024

#SARS-CoV-2 #BA4/5 #infection triggers more cross-reactive FcγRIIIa signaling and #neutralization than #BA1, in the context of #hybrid #immunity, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00678-24?af=R

Although this is consistent with enhanced neutralization and FcγRIIIa signaling breadth of BA.4/5 vaccine boosters, the reduced activity against #XBB15 supports the need to update vaccines with XBB sublineage immunogens to provide adequate coverage of these highly antibody evasive variants.

Giuseppe Michieli May 16, 2023

#Protection against #SARS-CoV-2 #Omicron #BA4/5 variant following #booster #vaccination or breakthrough infection in the #UK https://www.nature.com/articles/s41467-023-38275-1

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK - Nature Communications

The duration and strength of protection against SARS-CoV-2 infection resulting from a booster vaccine dose or breakthrough infection are not well understood. This study uses data from the UK COVID-19 Infection Survey to investigate correlates of protection against Omicron BA.4/5 infection and assess antibody responses to booster vaccination and breakthrough infections.

Nature

Giuseppe Michieli Mar 28, 2023

#mRNA #vaccines and hybrid #immunity use different B cell #germlines against #Omicron #BA4 and #BA5 https://www.nature.com/articles/s41467-023-37422-y

mRNA vaccines and hybrid immunity use different B cell germlines against Omicron BA.4 and BA.5 - Nature Communications

Omicron strains of SARS-CoV-2 have displayed high transmissibility and immunological escape to antibody responses derived from natural infection and vaccination. Here the authors compare the antibody response to vaccination and natural infection, assessing neutralisation after vaccine doses and analyse the repertoire of such responses.

Nature

Giuseppe Michieli Mar 14, 2023

Association of #SARS-CoV-2 #BA4/BA.5 #Omicron lineages with immune escape and #clinical outcome https://www.nature.com/articles/s41467-023-37051-5

Association of SARS-CoV-2 BA.4/BA.5 Omicron lineages with immune escape and clinical outcome - Nature Communications

Continuous monitoring of SARS-CoV-2 variant properties is important for public health planning. Here, the authors use data from the United States and show that Omicron BA.4/5 subvariants, which became dominant in mid-2022, have stronger immune escape properties, but are no more severe, than the previously dominant BA.2.

Nature

Giuseppe Michieli Mar 14, 2023

[Articles] Protective #immunity of #SARS-CoV-2 #infection and #vaccines against medically attended symptomatic #omicron #BA4, #BA5, and #XBB #reinfections in #Singapore: a national cohort study https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00060-9/fulltext?rss=yes

Protective immunity of SARS-CoV-2 infection and vaccines against medically attended symptomatic omicron BA.4, BA.5, and XBB reinfections in Singapore: a national cohort study

Protection against XBB reinfection conferred by a previous omicron infection with vaccination was lower and waned faster than protection against BA.4 or BA.5 reinfection, which is indicative of the greater immune evasiveness of the XBB sublineage. Although severe COVID-19 is uncommon, populations remain vulnerable to future reinfection waves from emerging SARS-CoV-2 variants despite high rates of vaccination and infection, as reflected by substantially higher reinfection rates during Singapore's XBB wave than during the previous BA.5-driven wave.

The Lancet Infectious Diseases

Giuseppe Michieli Mar 4, 2023

#Immunity of heterologous and homologous boosted or #convalescent individuals against #Omicron #BA1, #BA2 and #BA4/5 variants https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad057/7069351?rss=1

Giuseppe Michieli Feb 11, 2023

[Comment] Real-world #effectiveness of #nirmatrelvir–ritonavir against #BA4 and #BA5 #omicron #SARS-CoV-2 #variants https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00056-7/fulltext?rss=yes

Giuseppe Michieli Feb 11, 2023