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Wakefulness arises from multiple neuronal systems but it is unclear whether the same or different neurons are activated during pharmacological or non-pharmacological intervention. This study uses the TRAP2 mouse model to examine whole-brain activation patterns and shows that solriamfetol, modafinil and nonpharmacological arousal recruit overlapping but distinct subcortical populations.
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π§ New paper by Huang et al.: By using #pharmacological #fMRI and dynamic #connectome-based #PredictiveModeling, they show how #cortisol reshapes whole-brain #NetworkDynamics during emotional memory encoding. Trial-level analyses reveal distinct but increasingly integrated #arousal and #memory networks under #stress, supporting a hormonally driven "memory formation mode".
SpringGnoll
PLOS Biology
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Victoria Philippa Santiago
Fabrizio Musacchio
Rosie Red Bailey
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